Distribution of inorganic aryl and alkyl mercury compounds in rats

Journal Article · Mon Jan 01 00:00:00 EST 1968 · Toxicol. Appl. Pharmacol.; (United States)

DOI:https://doi.org/10.1016/0041-008X(68)90089-6· OSTI ID:6178153

Takeda, Y; Kunugi, T; Hoshino, O; Ukita, T

Mercuric chloride (MC), phenylmercuric chloride (PMC), ethylmercuric chloride (EMC), S-ethylmercuric cysteine (EMCys), and n-butylmercuric chloride (BMC) labeled with /sup 203/Hg were subcutaneously administered to rats, and the distribution and excretion of mercury were determined. In general, alkylmercury compounds (EMC, EMCys, and BMC) were excreted more slowly and were retained in higher concentration for a longer time in the body than MC and PMC. Several alkylmercury compounds revealed different metabolic behavior which depended on the carbon-chain length of the alkyl group. Distribution of mercury in the brain was found to depend on the structure of the mercury compounds. The relation between the neurotoxicity and the structure of the mercury compounds was discussed.

• Research Organization: Univ. of Tokyo, Japan
• OSTI ID: 6178153
• Journal Information: Toxicol. Appl. Pharmacol.; (United States), Vol. 13
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MERCURY COMPOUNDS
EXCRETION
TISSUE DISTRIBUTION
COMPARATIVE EVALUATIONS
METABOLISM
RATS
TOXICITY
UPTAKE
ANIMALS
CLEARANCE
DISTRIBUTION
MAMMALS
RODENTS
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)