Use of HPLC for the analytical determination of diisocyanates and acid anhydrides in the air of working environments
Measurements of airborne concentrations of (monomeric) 2,4- and 2,6- toluene diisocyanate (2,4- and 2,6- TDI), 4,4' - diisocyanato diphenylmethane (MDI) and phthalic anhydride have been performed at 17 Danish atmanufactories using these compounds in the production of polyurethane foams, insulating materials, elastomers, coatings, lacquers and glues. Diisocyanate vapors at workplaces were collected in impingers, containing a solution of 9-(N-methylaminomethyl)-anthracene (1 x 10/sup -4/ M) in toluene. By reaction with this amine compounds the diisocyanates are converted to stable urea derivatives. Phthalic anhydride particles were collected on glass fiber filters. For separation and detection of the diisocyanate derivatives and the phthalic acid formed upon hydrolysis of its anhydride, reversed phase high performance liquid chromatography on a bonded octadecylsilyl phase using isocratic elution with acetonitrile/water and UV-monitoring at lambda = 254 nm were used. The results obtained for each manufacturer are presented. 2 references, 3 figures, 1 table.
- Research Organization:
- Danish National Institute of Occupational Health, Hellerup
- OSTI ID:
- 6178082
- Journal Information:
- Anal. Lett.; (United States), Journal Name: Anal. Lett.; (United States) Vol. 18:A10; ISSN ANALB
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
400102* -- Chemical & Spectral Procedures
500200 -- Environment
Atmospheric-- Chemicals Monitoring & Transport-- (-1989)
54 ENVIRONMENTAL SCIENCES
570000 -- Health & Safety
99 GENERAL AND MISCELLANEOUS
AIR
AIR POLLUTION
AIR POLLUTION MONITORING
AIR QUALITY
ANHYDRIDES
CHEMICAL ANALYSIS
CHEMICAL REACTIONS
CHROMATOGRAPHY
DATA
DERIVATIZATION
ENVIRONMENTAL QUALITY
EXPERIMENTAL DATA
FILTERS
FILTRATION
FLUIDS
GASES
INFORMATION
ISOCYANATES
LIQUID COLUMN CHROMATOGRAPHY
NUMERICAL DATA
PARTICLES
PARTICULATES
POLLUTION
QUANTITATIVE CHEMICAL ANALYSIS
SEPARATION PROCESSES
WORKING CONDITIONS