Effect of phosphatidylserine on the basal and GABA-activated Cl- permeation across single nerve membranes from rabbit Deiters' neurons
Journal Article
·
· Neurochemical Research; (USA)
- Centro di Studio per la Neurofisiologia Cerebrale, C.N.R., Genova (Italy)
The permeation of labeled Cl- ions across single plasma membranes from Deiters' neurons has been studied in the presence of various concentrations of phosphatidylserine (PS) on their extracellular side. PS reduces significantly basal Cl- permeation only at 10(-5) M on the membrane exterior. No effect was found at other concentrations. GABA activable 36Cl- permeation is heavily reduced and almost abolished at 10(-11) - 10(-5) M phosphatidylserine. This exogenous phosphatidylserine effect is difficult to interpret in relation to the function of the endogenous phospholipid. However, it may be involved in the epileptogenic effect in vivo of exogenous phosphatidylserine administration to rats.
- OSTI ID:
- 6172784
- Journal Information:
- Neurochemical Research; (USA), Vol. 15:6; ISSN 0364-3190
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CELL MEMBRANES
PERMEABILITY
CHLORIDES
MEMBRANE TRANSPORT
PHOSPHOLIPIDS
BIOCHEMICAL REACTION KINETICS
AMINOBUTYRIC ACID
ANIONS
CHLORINE 36
INHIBITION
NERVE CELLS
RABBITS
TRACER TECHNIQUES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHARGED PARTICLES
CHLORINE COMPOUNDS
CHLORINE ISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HALIDES
HALOGEN COMPOUNDS
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
LIPIDS
MAMMALS
MEMBRANES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550201* - Biochemistry- Tracer Techniques
CELL MEMBRANES
PERMEABILITY
CHLORIDES
MEMBRANE TRANSPORT
PHOSPHOLIPIDS
BIOCHEMICAL REACTION KINETICS
AMINOBUTYRIC ACID
ANIONS
CHLORINE 36
INHIBITION
NERVE CELLS
RABBITS
TRACER TECHNIQUES
AMINO ACIDS
ANIMAL CELLS
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CELL CONSTITUENTS
CHARGED PARTICLES
CHLORINE COMPOUNDS
CHLORINE ISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ESTERS
HALIDES
HALOGEN COMPOUNDS
IONS
ISOTOPE APPLICATIONS
ISOTOPES
KINETICS
LIGHT NUCLEI
LIPIDS
MAMMALS
MEMBRANES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC PHOSPHORUS COMPOUNDS
RADIOISOTOPES
REACTION KINETICS
SOMATIC CELLS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550201* - Biochemistry- Tracer Techniques