Tracer kinetics of 15-(ortho-123/131I-phenyl)-pentadecanoic acid (oPPA) and 15-(para-123/131I-phenyl)-pentadecanoic acid (pPPA) in animals and man

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6170597

Kaiser, K P; Geuting, B; Grossmann, K; Vester, E; Loesse, B A; Antar, M A; Machulla, H J; Feinendegen, L E ^[1]

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1. Nuclear Research Center, Juelich (Germany, F.R.)

The human myocardium retains oPPA as opposed to pPPA. Therefore turnover of oPPA was compared with that of pPPA in rat hearts and in man, the latter by using substrates double-labeled with 123/131I and 14C. Moreover, substrate binding to coenzyme-A was tested in vitro. In rats, oPPA remained mainly in the pool of free fatty acids, as opposed to pPPA, which was metabolized by mitochondrial beta-oxidation. Binding to coenzyme-A at maximum was 62% for oPPA, 81% for pPPA and 90% for palmitic acid. In man, after i.v. and intracoronary injection of double-labeled oPPA, the two radionuclides reappeared together in venous blood and in coronary sinus respectively, in an unchanged ratio but at a significantly lower rate than with pPPA. It can be concluded that oPPA is bound to coenzyme-A and is retained in the cytosolic lipid pool, while pPPA is metabolized by mitochondrial beta-oxidation. A dual-tracer application of oPPA and pPPA has the potential of being a specific probe for the function of the carnitine shuttle.

• OSTI ID: 6170597
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:10; ISSN 0161-5505
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
RADIOPHARMACEUTICALS
METABOLISM
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
COENZYMES
COMPARATIVE EVALUATIONS
DOUBLE LABELLING
HEXADECANOIC ACID
IODINE 123
IODINE 131
MAN
MITOCHONDRIA
MYOCARDIUM
RATS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARBOXYLIC ACIDS
CARDIOVASCULAR SYSTEM
CELL CONSTITUENTS
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
HEART
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KINETICS
LABELLED COMPOUNDS
LABELLING
MAMMALS
MONOCARBOXYLIC ACIDS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANOIDS
ORGANS
PRIMATES
RADIOISOTOPES
REACTION KINETICS
RODENTS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics