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Operant behavior of rats exposed to lead before or after weaning

Journal Article · · Toxicol. Appl. Pharmacol.; (United States)
;

Rats were exposed to lead (Pb) before or after weaning. For preweaning exposures, nursing dams received 0.2% Pb acetate(1090 ppm Pb) in drinking water. Offspring treated after weaning consumed the same concentration. Tapwater served as the control fluid. Pre-post treatments were distributed among four experimental groups of 10 rats each: tap water-tap water, Pb-tap water, tap water-Pb, Pb-Pb. Operant behavior training began on Postnatal Day 58. Animals performed on a multiple reinforcement schedule of food presentation consisting of fixed-interval, fixed-ratio, and time out components.Statistical analyses of experimental sessions 4 to 11 (Postnatal Days 72 to 79) revealed that postweaning exposure significantly lengthened the median interval (interresponse time) between consecutive responses on both the interval and ratio schedules. Preweaning exposure alone tended to produce a shortening of the median interresponse time. Other performance indices and subsequence variations of ratio size showed similar but not significantly different relationships among the treatment groups. No significant histopathology was detected. Brain and blood Pb concentrations were consistent with the treatment protocol.

Research Organization:
Univ. of Rochester, NY
DOE Contract Number:
AC02-76EV03490
OSTI ID:
6169436
Journal Information:
Toxicol. Appl. Pharmacol.; (United States), Journal Name: Toxicol. Appl. Pharmacol.; (United States) Vol. 63; ISSN TXAPA
Country of Publication:
United States
Language:
English

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Related Subjects

560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEHAVIOR
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BRAIN
CENTRAL NERVOUS SYSTEM
CONCENTRATION RATIO
DRINKING WATER
ELEMENTS
HYDROGEN COMPOUNDS
INGESTION
INTAKE
LEAD
MAMMALS
MATERIALS
METALS
NERVOUS SYSTEM
ORGANS
OXYGEN COMPOUNDS
RATS
RESPONSE MODIFYING FACTORS
RODENTS
VERTEBRATES
WATER