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Hepatobiliary kinetics after whole-body irradiation

Technical Report ·
OSTI ID:6169289

The purpose of this investigation was to study hepatobiliary kinetics after whole-body gamma irradiation. Two groups of nine male beagle dogs were irradiated with a single whole body dose of 4- and 8-Gy cobalt-60 photons. Each animal was injected with 2 mCi Tc-99m DISIDA and scintigraphic studies were obtained with a gamma camera with a parallel hole multipurpose collimator. The parameters studied included: peak activity of the liver and gall bladder and gall bladder and intestinal visualization from the time of Tc-99m DISIDA administration. Total and indirect bilirubin, LDH, SGOT, and SGPT determined as baseline studies before irradiation and at different time intervals after irradiation were not changed in irradiated animals. Whole body Co-60 irradiation with 4 and 8 Gy produced no significant changes in the Tc-99m DISIDA visualization of the gall bladder or in the peak activity in the gall bladder or the liver 1 and 7 days after irradiation. Intestinal visualization occurred significantly earlier in 8 Gy Co-60 irradiated animals on both day 1 and day 7 post irradiation, compared to baseline values where it was never observed before 195.0 minutes. Gall bladder emptying is significantly accelerated after 8 Gy but not after 4-Gy Co-60 gamma irradiation. These observations suggest that gamma irradiation stimulates gall bladder contractility without modifying intrahepatic biliary kinetics.

Research Organization:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
OSTI ID:
6169289
Report Number(s):
AD-A-181851/7/XAB; AFRRI-SR-86-38
Country of Publication:
United States
Language:
English

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Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BEAMS
BILE
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY FLUIDS
CAMERAS
CONTRACTION
DIGESTIVE SYSTEM
DOGS
ELECTROMAGNETIC RADIATION
EXTERNAL IRRADIATION
GAMMA RADIATION
GLANDS
IONIZING RADIATIONS
IRRADIATION
KINETICS
LIVER
MALES
MAMMALS
MATERIALS
ORGANS
PHOTON BEAMS
RADIATION EFFECTS
RADIATIONS
VERTEBRATES
WHOLE-BODY IRRADIATION