Biological activity of phenolic compounds. Hepatic cytochrome P-450, cytochrome b/sub 5/ and NADPH cytochrome c reductase in chicks and rats fed phenolic monomers, polymers, and glycosides
Experiments were conducted to determine effects of a phenolic polymer (Kraft wood lignin, Indulin), phenolic glycosides (cane molasses and wood molasses), and phenolic monomers (vanillin, vanillic acid, ferulic acid, and p-coumaric acid) on liver cytochromes P-450, cytochrome b/sub 5/, and NADPH cytochrome c reductase in chicks and rats. Chicks fed 6.0% lignin had a higher cytochromes P-450 content than did chicks fed 0% fiber, 6.0% wood cellulose, or 6.0% arenaceous flour. Chicks fed 12.0% wood molasses had a higher cytochromes P-450 level than did chicks fed 0% fiber or 6.0% wood molasses. Cane molasses incorporated at both 6.0 and 12.0% of the diet induced cytochromes P-450 content over those of control-fed birds. Chicks fed 6.0% lignin, with or without antibiotic, had a higher cytochromes P-450 level than did chicks fed control diets, with or without antibiotic. Additionally, chicks fed 6.0% lignin had lower intestinal diaminopimelic acid (DAP) levels than did chicks fed 0% fiber. Rats fed 0% fiber, 6.0% wood cellulose, 6.0% arenaceous flour, or 6.0% lignin exhibited no difference in cytochrome level or activity among treatments. Chicks fed 0.5% vanillin, 0.5% vanillic acid, 0.5% ferulic acid, or 0.5% p-coumaric acid had comparable cytochromes level and activity compared with chicks fed no phenolics. Chicks fed 0.5% p-coumaric acid had lower rates of gain than did chicks fed control or other phenolic-containing diets. Rats fed these phenolics had similar cytochromes P-450 content among treatments.
- Research Organization:
- Univ. of Illinois, Urbana
- OSTI ID:
- 6165503
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 179:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
OXIDOREDUCTASES
ENZYME ACTIVITY
PHENOLS
TOXICITY
CHICKENS
CYTOCHROME OXIDASE
CYTOCHROMES
DOSE-RESPONSE RELATIONSHIPS
EXPERIMENTAL DATA
GLYCOSIDES
LIGNIN
LIVER
MOLASSES
MONOMERS
NADP
POLYMERS
RATS
ANIMALS
AROMATICS
BIRDS
BODY
CARBOHYDRATES
COENZYMES
DATA
DIGESTIVE SYSTEM
ENZYMES
FOWL
GLANDS
HAEM DEHYDROGENASES
HYDROXY COMPOUNDS
INFORMATION
MAMMALS
NUCLEOTIDES
NUMERICAL DATA
ORGANIC COMPOUNDS
ORGANS
PIGMENTS
POLYSACCHARIDES
RODENTS
SACCHARIDES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)