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Potentiation of cigarette smoking and radiation: evidence from a sputum cytology survey among uranium miners and controls

Journal Article · · Cancer; (United States)
; ; ; ;
To assess the effect of cigarette smoking and of exposure to radon daughters, a prospective survey consisting of periodic sputum cytology evaluation was initiated among 249 underground uranium miners and 123 male controls. Sputum cytology specimens showing moderate atypia, marked atypia, or cancer cells were classified as abnormal. As compared to control smokers, miners who smoke had a significantly higher incidence of abnormal cytology (P = 0.025). For miner smokers, the observed frequencies of abnormal cytology were linearly related to cumulative exposure to radon daughters and to the number of years of uranium mining. A statistical model relating the probability of abnormal cytology to the risk factors was investigated using a binary logistic regression. The estimated frequency of abnormal cytology was significantly dependent, for controls, on the duration of cigarette smoking, and for miners, on the duration of cigarette smoking and of uranium mining.
Research Organization:
Hospital Notre Dame, Montreal, Quebec
OSTI ID:
6161833
Journal Information:
Cancer; (United States), Journal Name: Cancer; (United States) Vol. 45:6; ISSN CANCA
Country of Publication:
United States
Language:
English

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054000 -- Nuclear Fuels-- Health & Safety
11 NUCLEAR FUEL CYCLE AND FUEL MATERIALS
560151* -- Radiation Effects on Animals-- Man
570000 -- Health & Safety
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
99 GENERAL AND MISCELLANEOUS
AEROSOLS
BIOLOGICAL MODELS
CARCINOGENESIS
COLLOIDS
DISPERSIONS
ELEMENTS
FLUIDS
GASES
IONIZING RADIATIONS
MATHEMATICAL MODELS
MINERS
MINES
NONMETALS
OCCUPATIONAL SAFETY
PATHOGENESIS
PERSONNEL
RADIATIONS
RADON
RARE GASES
RESIDUES
SAFETY
SMOKES
SOLS
STATISTICAL MODELS
SYNERGISM
TOBACCO PRODUCTS
TOBACCO SMOKES
URANIUM MINES