Role of thyroxine on postnatal development of ileal active bile salt transport

Journal Article · Fri Aug 01 04:00:00 EDT 1986 · Am. J. Physiol.; (United States)

OSTI ID:6154363

Heubi, J E

The role of thyroid hormone on the postnatal development of ileal active taurocholate transport uptake was measured by an in vitro incubation technique in Sprague-Dawley rats. In 16-day-old rats treated with pharmacological doses of L-thyroxine ileal active transport appeared precociously whose K/sub m/ was 1.60 +/- 0.48 mM and V/sub app/ was 8.09 +/- 1.14 nmol min mg dry wt , while age-matched shams had only passive diffusion of taurocholate. To determine whether enhanced endogenous secretion of thyroxine was capable of stimulating development of ileal active taurocholate transport, thyrotrophic stimulating hormone (TSH) was given on days 10-13, with uptake measured on day 16. Following TSH treatment, only passive transport for taurocholate was observed in the ileum; uptake rates were consistently higher than those for untreated controls at each study concentration. Thyroidectomy performed at age 14 days with uptake measured at age 21 days did not ablate development of ileal active transport but resulted in a significant reduction in the V/sub app/ and a significant increase in K/sub m/ compared with age-matched controls. Thyroid hormone does not appear to be obligatory for the postnatal development of ileal active taurocholate transport.

• Research Organization: Univ. of Cincinnati College of Medicine, OH
• OSTI ID: 6154363
• Journal Information: Am. J. Physiol.; (United States), Journal Name: Am. J. Physiol.; (United States) Vol. 251:2; ISSN AJPHA
• Country of Publication: United States
• Language: English

Related Subjects

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
ABSORPTION
AMINES
AMINO ACIDS
ANIMAL GROWTH
BILE ACIDS
BIOCHEMICAL REACTION KINETICS
BODY
CARBON 14 COMPOUNDS
CARBOXYLIC ACID SALTS
CARBOXYLIC ACIDS
CELL DIFFERENTIATION
CHOLIC ACID
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
GROWTH
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
INTESTINAL ABSORPTION
INTESTINES
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MEMBRANE TRANSPORT
NEONATES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC IODINE COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PEPTIDE HORMONES
PHYSIOLOGY
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOASSAY
RADIOIMMUNOLOGY
REACTION KINETICS
SECRETION
SMALL INTESTINE
STEROIDS
STEROLS
SULFONIC ACIDS
TAURINE
THYROID HORMONES
THYROXINE
TRACER TECHNIQUES
TSH
UPTAKE