Cardiac norepinephrine kinetics in hypertrophic cardiomyopathy

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Circulation; (United States)

DOI:https://doi.org/10.1161/01.CIR.79.4.836· OSTI ID:6150150

Brush, Jr, J E; Eisenhofer, G; Garty, M; Stull, R; Maron, B J; Cannon, III, R O; Panza, J A; Epstein, S E; Goldstein, D S

We examined the uptake and release of norepinephrine in the cardiac circulation and other regional vascular beds in 11 patients with hypertrophic cardiomyopathy (HCM) and in 10 control subjects during simultaneous infusion of tracer-labeled norepinephrine and isoproterenol. Cardiac neuronal uptake of norepinephrine was assessed by comparing regional removal of tracer-labeled norepinephrine with that of tracer-labeled isoproterenol (which is not a substrate for neuronal uptake) and by the relation between production of dihydroxyphenylglycol (DHPG), an exclusively intraneuronal metabolite of norepinephrine, and regional spillover of norepinephrine. Cardiac extraction of norepinephrine averaged 59 +/- 17% in the patients with HCM, significantly less than in the control subjects (79 +/- 13%, p less than 0.05), whereas cardiac extraction of isoproterenol was similar in the two groups (13 +/- 23% versus 13 +/- 14%), indicating that neuronal uptake of norepinephrine was decreased in the patients with HCM. The cardiac arteriovenous difference in norepinephrine was significantly larger in the patients with HCM than in the control subjects (73 +/- 77 versus 13 +/- 50 pg/ml, p less than 0.05), as was the product of the arteriovenous difference in norepinephrine and coronary blood flow (7.3 +/- 7.3 versus 0.8 +/- 3.0 ng/min, p less than 0.05).

• Research Organization: National Heart, Lung, and Blood Institute, Bethesda, MD (USA)
• OSTI ID: 6150150
• Journal Information: Circulation; (United States), Journal Name: Circulation; (United States) Vol. 79:4; ISSN CIRCA
• Country of Publication: United States
• Language: English

Related Subjects

550901* -- Pathology-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
ADRENAL HORMONES
ALCOHOLS
ANIMAL CELLS
AUTONOMIC NERVOUS SYSTEM AGENTS
BIOCHEMICAL REACTION KINETICS
BLOOD FLOW
BODY
CARDIOTONICS
CARDIOVASCULAR AGENTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
DISEASES
DRUGS
GLYCOLS
HEART
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MUSCLES
MYOCARDIUM
NERVE CELLS
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANS
PATHOGENESIS
PATIENTS
REACTION KINETICS
SOMATIC CELLS
SYMPATHOMIMETICS
TRACER TECHNIQUES
TRITIUM COMPOUNDS