Radiosurgery of acoustic neurinomas

Journal Article · Tue Jan 15 04:00:00 EST 1991 · Cancer (Philadelphia); (USA)

DOI:https://doi.org/10.1002/1097-0142(19910115)67:2<345::AID-CNCR2820670205>3.0.CO;2-M· OSTI ID:6146389

Flickinger, J C; Lunsford, L D; Coffey, R J; Linskey, M E; Bissonette, D J; Maitz, A H; Kondziolka, D ^[1]

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1. Univ. of Pittsburgh School of Medicine, PA (USA)

Eighty-five patients with acoustic neurinomas underwent stereotactic radiosurgery with the gamma unit at the University of Pittsburgh (Pittsburgh, PA) during its first 30 months of operation. Neuroimaging studies performed in 40 patients with more than 1 year follow-up showed that tumors were smaller in 22 (55%), unchanged in 17 (43%), and larger in one (2%). The 2-year actuarial rates for preservation of useful hearing and any hearing were 46% and 62%, respectively. Previously undetected neuropathies of the trigeminal (n = 12) and facial nerves (n = 14) occurred 1 week to 1 year after radiosurgery (median, 7 and 6 months, respectively), and improved at median intervals of 13 and 8 months, respectively, after onset. Hearing loss was significantly associated with increasing average tumor diameter (P = 0.04). No deterioration of any cranial nerve function has yet developed in seven patients with average tumor diameters less than 10 mm. Radiosurgery is an important treatment alternative for selected acoustic neurinoma patients.

• OSTI ID: 6146389
• Journal Information: Cancer (Philadelphia); (USA), Journal Name: Cancer (Philadelphia); (USA) Vol. 67:2; ISSN 0008-543X; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

550603* -- Medicine-- External Radiation in Therapy-- (1980-)
62 RADIOLOGY AND NUCLEAR MEDICINE
AUDITORY ORGANS
BODY
DISEASES
DOSES
MEDICINE
NEOPLASMS
NERVES
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
PATIENTS
POST-IRRADIATION EXAMINATION
RADIATION DOSES
RADIOLOGY
RADIOTHERAPY
SENSE ORGANS
SURVIVAL CURVES
THERAPY