In vitro effect of mercury and cadmium on brain Ca/sup 2 +/-ATPase of the catfish Ictalurus punctatus
Freshwater teleosts possess a calcium activated adenosine triphosphatase in the gills and brain which has an important role in calcium metabolism. Earlier studies have demonstrated that pesticides are found to inhibit the Ca/sup 2 +/-ATPase activity in the gills of fish. Although heavy metals have been shown to affect Na/sup +/-K/sup +/-ATPase in the brain and Ca/sup 2 +/-ATPase in the gills of fish, the mode of action of heavy metals on fish brain Ca/sup 2 +/-ATPase has not been clearly understood to date. Since heavy metals are known to produce neurotoxic action in higher vertebrates, the disruptive action of heavy metals on calcium pump in fish brain could be explained if they were found to affect this enzyme. Hence, this study was undertaken to evaluate the in vitro effect of divalent metals, mercury and cadmium on Ca/sup 2 +/-ATPase in the brain of catfish, Ictalurus punctatus.
- Research Organization:
- Univ. of Mississippi Medical Center, Jackson (USA)
- OSTI ID:
- 6143010
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ATP-ASE
BIOCHEMISTRY
CADMIUM CHLORIDES
BIOLOGICAL EFFECTS
CALCIUM COMPOUNDS
METABOLISM
MERCURY CHLORIDES
ABSORPTION SPECTROSCOPY
BRAIN
FISHES
ACID ANHYDRASES
ALKALINE EARTH METAL COMPOUNDS
ANIMALS
AQUATIC ORGANISMS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CENTRAL NERVOUS SYSTEM
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
ENZYMES
HALIDES
HALOGEN COMPOUNDS
HYDROLASES
MERCURY COMPOUNDS
MERCURY HALIDES
NERVOUS SYSTEM
ORGANS
PHOSPHOHYDROLASES
SPECTROSCOPY
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology