Correction of enzyme deficiency in mice by allogeneic bone marrow transplantation with total lymphoid irradiation
Journal Article
·
· Science (Washington, D.C.); (United States)
Enzyme deficiency was corrected in mice after allogeneic bone marrow transplantation with occurrence of graft versus host disease. Beta-Glucuronidase-deficient C3H/HeJ mice were treated with total lymphoid irradiation. Normal bone marrow cells (30 x 10(6)) from BALB/o to C3H/HeJ chimeras (> 90 percent circulating donor-type cells) without graft versus host disease. Beta-Glucuronidase activity increases to normal levels in all chimeras as measured in the liver and in the plasma. Activity was maintained throughout an observation period of 7 months.
- OSTI ID:
- 6141704
- Journal Information:
- Science (Washington, D.C.); (United States), Journal Name: Science (Washington, D.C.); (United States) Vol. 210:4474; ISSN SCIEA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CHIMERAS
ENZYME ACTIVITY
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HYDROLASES
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MICE
MOSAICISM
O-GLYCOSYL HYDROLASES
ORGANS
RADIATION CHIMERAS
RODENTS
TISSUES
TRANSPLANTS
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
ANIMALS
BODY
BONE MARROW
CHIMERAS
ENZYME ACTIVITY
ENZYMES
GLUCURONIDASE
GLYCOSYL HYDROLASES
GRAFT-HOST REACTION
HEMATOPOIETIC SYSTEM
HYDROLASES
IRRADIATION
LYMPHATIC SYSTEM
MAMMALS
MICE
MOSAICISM
O-GLYCOSYL HYDROLASES
ORGANS
RADIATION CHIMERAS
RODENTS
TISSUES
TRANSPLANTS
VERTEBRATES