Evaluation of toluene exposure via drinking water on levels of regional brain biogenic monoamines and their metabolites in CD-1 mice

Journal Article · Mon Oct 01 00:00:00 EDT 1990 · Ecotoxicology and Environmental Safety; (USA)

DOI:https://doi.org/10.1016/0147-6513(90)90056-B· OSTI ID:6139922

Hsieh, G C; Sharma, R P; Parker, R D; Coulombe, Jr, R A ^[1]

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1. Utah State Univ., Logan (USA)

Toluene, a potentially neurotoxic substance, is found in trace amounts in groundwater. Adult male CD-1 mice were continuously fed drinking water ad libitum containing 0, 17, 80, and 405 mg/liter toluene. After a 28-day treatment, animals were tested for endogenous levels of the biogenic monoamines norepinephrine (NE), dopamine (DA), and serotonin (5-HT) and their respective metabolites, 3-methoxy-4-hydroxymandelic acid (VMA), 3,4-dihydroxyphenylacetic acid (DOPAC), homovanillic acid (HVA), and 5-hydroxyindoleacetic acid (5-HIAA), in six discrete brain regions. The maximum toluene-induced increases of biogenic amines and their metabolites generally occurred at a toluene concentration of 80 mg/liter. In the hypothalamus, a major NE-containing compartment, the concentrations of NE significantly increased by 51, 63, and 34% in groups dosed with 17, 80, and 405 mg/liter, respectively. Significant increases of NE were also observed in the medulla oblongata and midbrain. Concomitantly, concentrations of VMA increased in various brain regions. Concentrations of DA were significantly higher in the corpus striatum and hypothalamus. Alterations in levels of DA metabolites, DOPAC and HVA, were marginal. Toluene significantly increased concentrations of 5-HT in all dissected brain regions, except cerebellum, and increased the 5-HIAA levels in the hypothalamus, corpus striatum, and cerebral cortex.

• OSTI ID: 6139922
• Journal Information: Ecotoxicology and Environmental Safety; (USA), Journal Name: Ecotoxicology and Environmental Safety; (USA) Vol. 20:2; ISSN EESAD; ISSN 0147-6513
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADRENAL HORMONES
ALKYLATED AROMATICS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
AZAARENES
AZOLES
BIOSYNTHESIS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CONTAMINATION
DOPAMINE
DRINKING WATER
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
INDOLES
INGESTION
INTAKE
MAMMALS
METABOLISM
METABOLITES
MICE
NERVOUS SYSTEM
NEUROREGULATORS
NORADRENALINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PHENOLS
POLLUTION
POLYPHENOLS
PYRROLES
RADIOPROTECTIVE SUBSTANCES
RODENTS
SEROTONIN
SYMPATHOMIMETICS
SYNTHESIS
TOLUENE
TRYPTAMINES
VERTEBRATES
WATER
WATER POLLUTION