The U. S. Environmental Protection Agency's risk assessment guidelines

Journal Article · Mon Oct 01 04:00:00 EDT 1990 · Toxicology and Industrial Health; (USA)

OSTI ID:6139878

Jarabek, A M; Farland, W H ^[1]

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1. Environmental Protection Agency Office of Health, Research Triangle Park, NC (USA)

This paper has been reviewed by the Office of Health and Environmental Assessment, U.S. Environmental Protection Agency, and approved for publication. Approval does not signify that the contents necessarily reflect the views and policies of the Agency, nor does mention of trade names or commercial products constitute endorsement or recommendation for use. In 1983, the U.S. National Academy of Sciences (U.S. NAS) proposed a framework for the processes of risk assessment and risk management in government agencies (U.S. NAS, 1983). Using the U.S. NAS scheme as an organizing principle, the U.S. Environmental Protection Agency (U.S. EPA) published guidelines pertaining to risk assessment in five areas: estimating exposures, chemical mixtures, mutagenicity, suspect developmental toxicity and carcinogenicity. These guidelines were developed to promote high technical quality and consistent practice of risk assessment Agencywide. This paper will discuss the historical development of the guidelines and their role in the work performed by the Agency. Each of the five (5) guidelines is outlined and anticipated revisions discussed. Related assessment activities and new subject areas are also presented. 14 refs.

• OSTI ID: 6139878
• Journal Information: Toxicology and Industrial Health; (USA), Journal Name: Toxicology and Industrial Health; (USA) Vol. 6:5; ISSN TIHEE; ISSN 0748-2337
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
CARCINOGENESIS
MAMMALS
MAN
MUTAGENESIS
NATIONAL ORGANIZATIONS
PATHOGENESIS
PRIMATES
RECOMMENDATIONS
RISK ASSESSMENT
US EPA
US ORGANIZATIONS
VERTEBRATES
XENOBIOTICS