Parathyroid adenomas following irradiation

Journal Article · Thu Mar 01 04:00:00 EST 1979 · Cancer; (United States)

DOI:https://doi.org/10.1002/1097-0142(197903)43:3<1078::AID-CNCR2820430344>3.0.CO;2-R· OSTI ID:6137918

Russ, J E; Scanlon, E F; Sener, S F

Parathyroid adenomas have been demonstrated to occur following external head and neck irradiaion. The median latency interval is 30 years. In a series of 74 consecutive patients with histologically diagnosed parathyroid adenomas, 25% gave a history of prior radiation exposure. When compared to a matched control incidence of 7.9%, statistical significance is reached at p < 0.01. Thyroid abnormalities were present in 68% of the irradiated patients, and 30% of these were malignant. Tumors of skin, breast, and parotid gland also occurred more frequently than expected. Forty-seven percent of the irradiated group had malignant neoplasms within the radiaiton field. The histopathology of the radiation-associated parathyroid adenomas is similar to that seen experimentally.

• OSTI ID: 6137918
• Journal Information: Cancer; (United States), Journal Name: Cancer; (United States) Vol. 43:3; ISSN CANCA
• Country of Publication: United States
• Language: English

Related Subjects

560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ADENOMAS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
DATA
DATA FORMS
DELAYED RADIATION EFFECTS
DISEASES
ENDOCRINE GLANDS
EXPERIMENTAL DATA
GLANDS
HEAD
INFORMATION
ISOLATED VALUES
MAMMARY GLANDS
MEDICINE
NECK
NEOPLASMS
NUCLEAR MEDICINE
NUMERICAL DATA
ORGANS
PARATHYROID GLANDS
RADIATION EFFECTS
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SALIVARY GLANDS
SIDE EFFECTS
SKIN
THERAPY