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Experimental in vivo imaging of the cranial perineural lymphatic pathway

Journal Article · · AJNR, Am. J. Neuroradiol.; (United States)
OSTI ID:6136807
; ; ; ;
After intraventricular injection of 99mTc antimony sulfide in rabbits (n . 12) and cats (n . 14), radiolabeled colloid was imaged passing into the nasal mucosa and subsequently into the cervical lymph nodes. The cervical lymph nodes accounted for about 12% of the injected dose in rabbits sacrificed at 22-24 hr after injection and about 5% of the injected dose in cats sacrificed at 5-6 hr after injection. In both animals this represented at least one-third of the cerebrospinal fluid colloid clearance. This technique is applicable to in vivo imaging studies of the perineural lymphatic pathway for cerebrospinal fluid absorption in primates and, with modifications, in human subjects.
Research Organization:
Massachusetts General Hospital, Boston
OSTI ID:
6136807
Journal Information:
AJNR, Am. J. Neuroradiol.; (United States), Journal Name: AJNR, Am. J. Neuroradiol.; (United States) Vol. 5:5; ISSN AAJND
Country of Publication:
United States
Language:
English

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Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
ANTIMONY COMPOUNDS
ANTIMONY SULFIDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL MATERIALS
BIOLOGICAL MODELS
BIOLOGICAL PATHWAYS
BODY
BODY AREAS
BODY FLUIDS
CATS
CEREBROSPINAL FLUID
CHALCOGENIDES
COLLOIDS
COUNTING TECHNIQUES
DISPERSIONS
DISTRIBUTION
FACE
HEAD
HOURS LIVING RADIOISOTOPES
IN VIVO
INTERMEDIATE MASS NUCLEI
ISOMERIC NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LYMPH NODES
LYMPHATIC SYSTEM
MAMMALS
MATERIALS
MEMBRANES
MUCOUS MEMBRANES
NOSE
NUCLEI
ODD-EVEN NUCLEI
RABBITS
RADIOCOLLOIDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RESPIRATORY SYSTEM
SULFIDES
SULFUR COMPOUNDS
TECHNETIUM 99
TECHNETIUM ISOTOPES
TISSUE DISTRIBUTION
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOISOTOPES