Mutagenic and carcinogenic activity of a hydrotreated coal liquid

Journal Article · Sun Jan 01 04:00:00 EST 1984 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398409530518· OSTI ID:6135236

Frazier, M E; Mahlum, D D

A fuel-oil blend (FOB) and its hydrotreated product from the solvent-refined coal (SRC) II process were evaluated for their mutagenic and carcinogenic potential. The FOB was highly active in both cellular assays, as well as in animal (skin-painting) studies. Cell-transforming and mutagenic activities of hydrotreated FOB were consistently found to be lower than for untreated FOB. Finally, while most of the initiating activity (in the animal assay) was lost following hydrotreatment, the data indicate that the hydrotreated FOB still had significant skin-tumor-promoting activity. 19 references, 4 figures, 2 tables.

• Research Organization: Pacific Northwest Lab., Richland, WA
• OSTI ID: 6135236
• Journal Information: J. Toxicol. Environ. Health; (United States), Journal Name: J. Toxicol. Environ. Health; (United States) Vol. 13:4-6; ISSN JTEHD
• Country of Publication: United States
• Language: English

Related Subjects

01 COAL, LIGNITE, AND PEAT
016000 -- Coal
Lignite
& Peat-- Health & Safety
560301* -- Chemicals Metabolism & Toxicology-- Cells-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BODY
CARCINOGENESIS
COAL LIQUEFACTION
COAL LIQUIDS
DATA
EXPERIMENTAL DATA
FLUIDS
INFORMATION
LIQUEFACTION
LIQUIDS
MUTAGEN SCREENING
MUTAGENESIS
NUMERICAL DATA
ORGANS
PATHOGENESIS
SCREENING
SKIN
SRC-II PROCESS
THERMOCHEMICAL PROCESSES