Occupational exposures among fathers of children with Wilms tumor
An occupation-and-exposure linkage system was utilized to perform an epidemiologic case-control study of paternal occupation and Wilms tumor in offspring. The first part of the study was designed to test the hypothesis that paternal lead (Pb) exposure is a risk factor for Wilms tumor in offspring. The second part of the study was an exploratory analysis that sought to generate possible etiologic hypotheses about other paternal exposures in the workplace in relation to Wilms tumor. Calculation of odds ratios indicated that there was no statistical difference in the frequency of occupational exposure to Pb, Pb alkyls, and Pb salts for fathers of children with Wilms' tumor and fathers of controls, a finding that contrasts sharply with the results of the one previously reported study in this area. In the exploratory phase of the study, case fathers were found more likely to have been exposed to boron, while control fathers were found more likely to have encountered insecticides, acetylene, o-chlorobenzylidene, oil orange ss, and diethylene glycol; the differences were statistically significant. Troublesome methodologic problems, including exposure misclassification, sample size, and multiple comparisons, are discussed.
- Research Organization:
- Ohio State Univ., Columbus
- OSTI ID:
- 6128784
- Journal Information:
- JOM, J. Occup. Med.; (United States), Vol. 26:6
- Country of Publication:
- United States
- Language:
- English
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BORON
HEALTH HAZARDS
HYDROCARBONS
KIDNEYS
NEOPLASMS
LEAD COMPOUNDS
ETIOLOGY
CHILDREN
EPIDEMIOLOGY
GENETIC EFFECTS
MEN
OCCUPATIONAL EXPOSURE
AGE GROUPS
ANIMALS
BIOLOGICAL EFFECTS
BODY
DISEASES
ELEMENTS
HAZARDS
MALES
MAMMALS
MAN
ORGANIC COMPOUNDS
ORGANS
PRIMATES
SEMIMETALS
VERTEBRATES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)