Myelography and cytology in the treatment of medulloblastoma

Conference · Mon Jun 01 04:00:00 EDT 1981 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

OSTI ID:6122142

Deutsch, M ^[1]; Reigel, D H

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1. Univ. Health Center of Pittsburgh, PA

Eight of 22 children with newly diagnosed medulloblastoma had asymptomatic spinal cord involvement detected by myelography. Two additional patients had demonstrable spinal cord lesions at the time of relapse in the posterior fossa. Cerebral spinal fluid (CSF) cytology results were inaccurate in predicting cord involvement. Seven patients have relapsed 9 to 69 months from completion of radiotherapy. Three had initial cord involvement and also had subsequent cord involvement at the time of intracranial relapse or afterwards. Frontal lobe involvement as the initial site of relapse occurred in 3 patients. Computerized tomography has been valuable in the early detection of intracranial relapse. Three children are alive and well 10, 18 and 19 months, respectively, from time of relapse. All were retreated with radiotherapy in conjunction with misonidazole and subsequent chemotherapy.

• OSTI ID: 6122142
• Conference Information: Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Journal Volume: 7:6
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AGE GROUPS
ANTINEOPLASTIC DRUGS
AZOLES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGY
BODY
BODY FLUIDS
BRAIN
CARCINOMAS
CENTRAL NERVOUS SYSTEM
CEREBROSPINAL FLUID
CHILDREN
COMPUTERIZED TOMOGRAPHY
CYTOLOGY
DIAGNOSIS
DIAGNOSTIC TECHNIQUES
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
MATERIALS
MEDICINE
METASTASES
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PATIENTS
RADIATION EFFECTS
RADIOLOGY
RADIOSENSITIZERS
RADIOTHERAPY
SPINAL CORD
THERAPY
TOMOGRAPHY