Secondary Ph-positive CML with a minority monosomy 7 clone
We report a case of Ph-positive chronic myelogenous leukemia (CML) secondary to previous treatment for a lymphoma. At the time of original diagnosis of lymphoblastic lymphoma, chromosome studies of blood and bone marrow were normal. Following therapy and a clinical remission complicated by CNS relapse, the patient presented 16 months after treatment was discontinued with a WBC of 110,000 mm-3, consistent with CML. Blood and marrow cytogenetic studies at this time showed a Ph chromosome, t(9;22)(q34;q11) translocation, without other karyotypic alteration. A separate small clone with the karyotype 45,XY, -7 was found in the blood. His disease followed an aggressive course and he died 3 months later. The autopsy findings indicated CML in blast crisis. Molecular studies performed on cells replacing a lymph node revealed a rearrangement of the breakpoint cluster region (bcr) of chromosome number22 and of the immunoglobulin heavy chain locus. Taken together, it seems most likely that the patient's CML developed as a second neoplasm following successful elimination of his lymphoblastic lymphoma by therapy.
- Research Organization:
- Univ. of Pennsylvania School of Medicine, Philadelphia
- OSTI ID:
- 6121759
- Journal Information:
- Cancer Genet. Cytogenet.; (United States), Journal Name: Cancer Genet. Cytogenet.; (United States) Vol. 28:1; ISSN CGCYD
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL TISSUES
AUTOPSY
BIOLOGICAL MATERIALS
BLOOD
BODY
BODY FLUIDS
BONE MARROW
CELL CULTURES
CHROMOSOMES
CLONE CELLS
DIAGNOSTIC TECHNIQUES
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HEMATOPOIETIC SYSTEM
HEMIC DISEASES
LEUKEMIA
LYMPHOMAS
MATERIALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANS
PATIENTS
PHILADELPHIA CHROMOSOME
RADIOINDUCTION
RADIOLOGY
RADIOTHERAPY
SIDE EFFECTS
THERAPY
TISSUES