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Title: Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma

Abstract

Adenocarcinoma of the ethmoid sinus is rare, representing only 4 to 8% of malignancies of the paranasal sinuses. An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. Histologically, the findings of a papillary pattern of poorly differentiated, mucicarmine-staining cells enclosing gland-like spaces, and the absence of pseudorosettes, melanin, mesenchymal and peripheral neural elements supports an epithelial origin of this tumor. The high incidence of second fatal primary neoplasms in patients with bilateral retinoblastomas receiving radiation suggests an innate susceptibility that may add to the risk of radiotherapy. Careful long-term head and neck surveillance is mandatory if early aggressive management of these extremely lethal tumors is to be successful.

Authors:
; ;
Publication Date:
Research Org.:
Univ. of California, San Francisco
OSTI Identifier:
6120469
Resource Type:
Journal Article
Journal Name:
Laryngoscope; (United States)
Additional Journal Information:
Journal Volume: 80:1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; RADIOINDUCTION; PHARYNX; DELAYED RADIATION EFFECTS; RADIOTHERAPY; SIDE EFFECTS; HISTOLOGY; BIOLOGICAL EFFECTS; BIOLOGICAL RADIATION EFFECTS; BODY; DIGESTIVE SYSTEM; DISEASES; MEDICINE; NEOPLASMS; NUCLEAR MEDICINE; ORGANS; RADIATION EFFECTS; RADIOLOGY; RESPIRATORY SYSTEM; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Rowe, L D, Lane, R, and Snow, Jr, J B. Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma. United States: N. p., 1980. Web. doi:10.1288/00005537-198001000-00007.
Rowe, L D, Lane, R, & Snow, Jr, J B. Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma. United States. doi:10.1288/00005537-198001000-00007.
Rowe, L D, Lane, R, and Snow, Jr, J B. Tue . "Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma". United States. doi:10.1288/00005537-198001000-00007.
@article{osti_6120469,
title = {Adenocarcinoma of the ethmoid following radiotherapy for bilateral retinoblastoma},
author = {Rowe, L D and Lane, R and Snow, Jr, J B},
abstractNote = {Adenocarcinoma of the ethmoid sinus is rare, representing only 4 to 8% of malignancies of the paranasal sinuses. An extraordinary case of papillary adenocarcinoma of the ethmoid sinus arising 30 years following high-dose radiotherapy for bilateral retinoblastoma is presented. Histologically, the findings of a papillary pattern of poorly differentiated, mucicarmine-staining cells enclosing gland-like spaces, and the absence of pseudorosettes, melanin, mesenchymal and peripheral neural elements supports an epithelial origin of this tumor. The high incidence of second fatal primary neoplasms in patients with bilateral retinoblastomas receiving radiation suggests an innate susceptibility that may add to the risk of radiotherapy. Careful long-term head and neck surveillance is mandatory if early aggressive management of these extremely lethal tumors is to be successful.},
doi = {10.1288/00005537-198001000-00007},
journal = {Laryngoscope; (United States)},
number = ,
volume = 80:1,
place = {United States},
year = {1980},
month = {1}
}