Cobalamin inactivation by nitrous oxide produces severe neurological impairment in fruit bats: protection by methionine and aggravation by folates
Journal Article
·
· Life Sci.; (United States)
Nitrous oxide, which inactivates cobalamin when administered to fruit bats, results in severe neurological impairment leading to ataxia, paralysis and death. This occurs after about 6 weeks in animals depleted of cobalamin by dietary restriction, and after about 10 weeks in cobalamin replete bats. Supplementation of the diet with pteroylglutamic acid caused acceleration of the neurological impairment--the first unequivocal demonstration of aggravation of the neurological lesion in cobalamin deficiency by pteroylglutamic acid. The administration of formyltetrahydropteroylglutamic acid produced similar aggravation of the neurological lesion. Supplementation of the diet with methionine protected the bats from neurological impairment, but failed to prevent death. Methionine supplementation protected against the exacerbating effect of folate, preventing the development of neurological changes. These findings lend support to the hypothesis that the neurological lesion in cobalamin deficiency may be related to a deficiency in the methyl donor S-adenosylmethionine which follows diminished synthesis of methionine.
- Research Organization:
- South African Inst. for Medical Research, Johannesburg, South Africa
- OSTI ID:
- 6117790
- Journal Information:
- Life Sci.; (United States), Journal Name: Life Sci.; (United States) Vol. 31:18; ISSN LIFSA
- Country of Publication:
- United States
- Language:
- English
Similar Records
The role of methionine in the intracellular accumulation and function of folates
Folate-dependent enzymes in cultured Chinese hamster ovary cells: induction of 5-methyltetrahydrofolate homocysteine cobalamin methyltransferase by folate and methionine
Increased folate uptake prevents dietary development of folate deficiency in the rat brain
Journal Article
·
Fri Dec 31 23:00:00 EST 1982
· Adv. Exp. Med. Biol.; (United States)
·
OSTI ID:5513619
Folate-dependent enzymes in cultured Chinese hamster ovary cells: induction of 5-methyltetrahydrofolate homocysteine cobalamin methyltransferase by folate and methionine
Journal Article
·
Tue Dec 31 23:00:00 EST 1974
· Arch. Biochem. Biophys.; (United States)
·
OSTI ID:7355003
Increased folate uptake prevents dietary development of folate deficiency in the rat brain
Conference
·
Sun Feb 25 23:00:00 EST 1990
· FASEB Journal (Federation of American Societies for Experimental Biology); (United States)
·
OSTI ID:6006315
Related Subjects
560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BATS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHALCOGENIDES
DRUGS
FOLIC ACID
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INACTIVATION
INJURIES
LIPOTROPIC FACTORS
MAMMALS
METHIONINE
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PTERIDINES
RESPONSE MODIFYING FACTORS
VERTEBRATES
VITAMIN B GROUP
VITAMIN B-12
VITAMINS
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AMINO ACIDS
ANIMALS
BATS
BIOLOGICAL EFFECTS
CARBOXYLIC ACIDS
CHALCOGENIDES
DRUGS
FOLIC ACID
HEMATINICS
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INACTIVATION
INJURIES
LIPOTROPIC FACTORS
MAMMALS
METHIONINE
NERVOUS SYSTEM
NITROGEN COMPOUNDS
NITROGEN OXIDES
NITROUS OXIDE
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PTERIDINES
RESPONSE MODIFYING FACTORS
VERTEBRATES
VITAMIN B GROUP
VITAMIN B-12
VITAMINS