Lactate rise detected by sup 1 H NMR in human visual cortex during physiologic stimulation

Journal Article · Mon Jul 01 04:00:00 EDT 1991 · Proceedings of the National Academy of Sciences of the United States of America; (United States)

DOI:https://doi.org/10.1073/pnas.88.13.5829· OSTI ID:6100252

Prichard, J; Rothman, D; Novotny, E; Petroff, O; Kuwabara, Takeo; Avison, M; Howseman, A; Shulman, R ^[1]; Hanstock, C ^[2]

---

1. Yale Medical School, New Haven, CT (United States)
2. Univ. of Alberta, Edmonton (Canada)

Brain lactate concentration is usually assumed to be stable except when pathologic conditions cause a mismatch between glycolysis and respiration. Using newly developed {sup 1}H NMR spectroscopic techniques that allow measurement of lactate in vivo, the authors detected lactate elevations of 0.3-0.9 mM in human visual cortex during physiologic photic stimulation. The maximum rise appeared in the first few minutes; thereafter lactate concentration declined while stimulation continued. The results are consistent with a transient excess of glycolysis over respiration in the visual cortex, occurring as a normal response to stimulation in the physiologic range.

• OSTI ID: 6100252
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (United States), Journal Name: Proceedings of the National Academy of Sciences of the United States of America; (United States) Vol. 88:13; ISSN PNASA; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

550201* -- Biochemistry-- Tracer Techniques
59 BASIC BIOLOGICAL SCIENCES
BIOCHEMISTRY
BODY
BODY AREAS
CARBOXYLIC ACIDS
CHEMISTRY
EYES
FACE
HEAD
HYDROXY ACIDS
INTERNATIONAL ORGANIZATIONS
LACTIC ACID
MAGNETIC RESONANCE
MEDICINE
NEA
NEUROLOGY
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
OECD
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANS
PATIENTS
RESONANCE
RETINA
SENSE ORGANS
SPECTRA
VISION