Accelerated heavy particles and the lens. III. Cataract enhancement by dose fractionation

Journal Article · Sat Apr 01 04:00:00 EST 1989 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577425· OSTI ID:6097023

Worgul, B V; Merriam, Jr, G R; Medvedovsky, C; Brenner, D J

For a number of biological end points it has been shown that, in contrast to low linear energy transfer (LET) radiation, dose fractionation of high-LET radiation does not result in a reduction in overall effectiveness. Studies were conducted to determine the effect of fractionating the exposures to heavy ion doses on the development of cataracts. Rat eyes were exposed to single doses of 1, 5, and 25 cGy of 570 MeV/amu40Ar ions and to 2, 4, and 10 Gy of 250 kVp X rays. These were compared to unirradiated controls and eyes which were exposed to the same total dose delivered in four fractions over 12 h. While in all cases fractionation of the exposure to X rays produced significant reduction in cataractogenic potential, fractionating doses of 40Ar ions caused a dose- and stage-dependent enhancement in the development of cataracts.

• Research Organization: Columbia Univ., New York, NY (USA)
• OSTI ID: 6097023
• Journal Information: Radiat. Res.; (United States), Journal Name: Radiat. Res.; (United States) Vol. 118:1; ISSN RAREA
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BODY
BODY AREAS
CATARACTS
CRYSTALLINE LENS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DOSES
ELECTROMAGNETIC RADIATION
ENERGY TRANSFER
EYES
FACE
FRACTIONATED IRRADIATION
HEAD
IONIZING RADIATIONS
IRRADIATION
LET
MAMMALS
ORGANS
RADIATION DOSES
RADIATIONS
RADIOINDUCTION
RATS
RBE
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
X RADIATION