Effect of adriamycin and actinomycin D on radiation-induced skin reactions in mouse feet. [X rays]

Journal Article · Sun Apr 01 04:00:00 EST 1979 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(79)90810-1· OSTI ID:6095851

Redpath, J L; Colman, M

The effects of adriamycin (10 mg/kg, i.p.) and actinomycin D (0.7 mg/kg, i.p.) on radiation-induced skin reactions in mouse feet have been examined. Drugs were administered either 24 or 2 hr before, or 24 hr after single doses of 6 MeV photons. Split radiation dose experiments were also performed with the drug being administered either 24 or 2 hr before the first radiation dose. A five daily fraction experiment with drug administered 2 hr before the first and third doses was also carried out. In none of these experiments did adriamycin alter the kinetics of appearance, or the severity of, the radiation-induced reaction. Furthermore, drug administered 30 days after the radiation dose, i.e. after the radiation reaction was healed, did not induce and further reaction. These results confirm our previous preliminary observations that adriamycin does not significantly enhance radiation damage to the skin of mouse feet. In the case of actinomycin D no enhancement of skin reaction in single radiation dose experiments was observed. However, in both the split dose and five fraction study a significantly more severe skin reaction was seen in the drug treated animals compared to those treated with radiation alone.

• Research Organization: Univ. of California, Irvine
• OSTI ID: 6095851
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 5:4; ISSN IOBPD
• Country of Publication: United States
• Language: English

Related Subjects

560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACTINOMYCIN
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMALS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
BODY AREAS
COMPARATIVE EVALUATIONS
DATA
DATA FORMS
DISEASES
DOSE-RESPONSE RELATIONSHIPS
DRUGS
ELECTROMAGNETIC RADIATION
EPILATION
ERYTHEMA
EXPERIMENTAL DATA
FEET
FRACTIONATED IRRADIATION
INFORMATION
IONIZING RADIATIONS
IRRADIATION
ISOLATED VALUES
LEGS
LIMBS
LOCAL IRRADIATION
MAMMALS
MICE
NECROSIS
NUMERICAL DATA
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RESPONSE MODIFYING FACTORS
RODENTS
SKIN
SYMPTOMS
TIME DEPENDENCE
VERTEBRATES
X RADIATION