Trimethyltin retinopathy: relationship of subcellular response to neuronal subspecialization

Journal Article · Thu Mar 01 04:00:00 EST 1984 · J. Neuropathol. Exp. Neurol.; (United States)

DOI:https://doi.org/10.1097/00005072-198403000-00006· OSTI ID:6093462

Bouldin, T W; Goines, N D; Krigman, M R

Retinal neurons from rats acutely intoxicated with trimethyltin (TMT) were examined by light and electron microscopy to determine if there is a relationship between the subcellular response of a neuron to TMT and its morphologic subspecialization. Subcellular pathologic alterations were present in neurons from all three cellular layers of the sensory retina. However, the type and degree of subcellular response varied among the highly subspecialized neurons of the different retinal layers. Clusters of dense-cored vesicles and tubules were mainly limited to neurons of the ganglion-cell layer, large accumulations of dense bodies were mainly limited to neurons of the inner nuclear layer, and neuronal necrosis was mainly limited to the photoreceptor cells. The inner segment of the photoreceptor cell shared with the perikaryon of more conventional neurons a special vulnerability to TMT cytotoxicity. Our results suggest that the subspecialization of neurons affects the type and the degree of subcellular response to TMT.

• Research Organization: Univ. of North Carolina School of Medicine, Chapel Hill
• OSTI ID: 6093462
• Journal Information: J. Neuropathol. Exp. Neurol.; (United States), Journal Name: J. Neuropathol. Exp. Neurol.; (United States) Vol. 43:2; ISSN JNENA
• Country of Publication: United States
• Language: English

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560305* -- Chemicals Metabolism & Toxicology-- Vertebrates-- (-1987)
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
CELL CONSTITUENTS
DISEASES
ELECTRON MICROSCOPY
ENDOPLASMIC RETICULUM
EYES
FACE
HEAD
MAMMALS
MICROSCOPY
NERVE CELLS
NERVOUS SYSTEM DISEASES
ORGANIC COMPOUNDS
ORGANOIDS
ORGANOMETALLIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RATS
RETINA
RODENTS
SENSE ORGANS
SOMATIC CELLS
TIN COMPOUNDS
VERTEBRATES