Health risk assessment of chloroform in California ground water

Technical Report · Mon Jan 20 04:00:00 EST 1992

OSTI ID:6086227

Bogen, K T; Hall, L C; McKone, T E

This document presents an assessment of potential health risks associated with exposure to chloroform dissolved in California ground waters used for domestic consumption, focusing primarily on information relevant to a determination of potential increased cancer risk that may be associated with such exposures to chloroform. This assessment is being provided to the California Department of Health Services (CDHS) for the development of drinking-water standards to manage the health risks of chloroform exposures. Other assessments required in the risk-management process include analyses of the technical and economic feasibilities of treating water supplies contaminated with chloroform. The primary goal of this health-risk assessment is to describe scientifically plausible dose-response relationships for chloroform-induced cancer observed experimentally in animal bioassays that are relevant to the estimation of potential cancer risk in humans. This document is intended to provide a scientific basis for regulatory selection of chloroform concentrations in California groundwater predicted to protect the general public from potential health risk, focusing on potential cancer risk in particular. To this end, we also analyze the extent of human exposures attributable to chloroform-contaminated groundwater in California. A separate health-risk assessment for potential toxic endpoints other than cancer that may be associated with water-based exposure to chloroform has been prepared by CDHS (1989).

• Research Organization: Lawrence Livermore National Lab., CA (United States)
• Sponsoring Organization: DOHHS; Department of Health and Human Services, Washington, DC (United States)
• DOE Contract Number: W-7405-ENG-48
• OSTI ID: 6086227
• Report Number(s): UCRL-21170; ON: DE93014119
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
540220* -- Environment
Terrestrial-- Chemicals Monitoring & Transport-- (1990-)
560300 -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BIOLOGICAL EFFECTS
CHEMICAL PROPERTIES
CHLORINATED ALIPHATIC HYDROCARBONS
CHLOROFORM
DISEASES
GROUND WATER
HALOGENATED ALIPHATIC HYDROCARBONS
HAZARDS
HEALTH HAZARDS
HYDROGEN COMPOUNDS
LAWRENCE LIVERMORE LABORATORY
METABOLISM
NATIONAL ORGANIZATIONS
NEOPLASMS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
OXYGEN COMPOUNDS
PHARMACOLOGY
PHYSICAL PROPERTIES
PUBLIC HEALTH
RISK ASSESSMENT
US AEC
US DOE
US ERDA
US ORGANIZATIONS
WATER