Diagnosis of biliary atresia with radionuclide hepatobiliary imaging

Journal Article · Tue Feb 01 00:00:00 EST 1983 · Radiology; (United States)

DOI:https://doi.org/10.1148/radiology.146.2.6681570· OSTI ID:6085967

Gerhold, J P; Klingensmith, III, W C; Kuni, C C; Lilly, J R; Silverman, A; Fritzberg, A R; Nixt, T L

Sixteen patients with biliary atresia and 11 patients with neonatal hepatitis were studied preoperatively with either Tc99m-diethyl-IDA or Tc99m-diisopropyl-IDA. Two parameters were evaluated: hepatocyte clearance and time to appearance of radioactivity in the intestine. Two observers, using a visual grading system of 1 to 4, gave the 16 patients with biliary atresia a hepatocyte clearance grade of 1.7 +/- 0.6 (mean +/- SD); intestinal radioactivity was not seen through 24 hours. The hepatocyte clearance grade of the 11 patients with neonatal hepatitis was 2.1 +/- 0.9 (mean +/- SD) (p>0.05); intestinal radioactivity was seen in nine of 11 patients (p<0.001). Using both parameters, 91% of the patients were classified correctly, 4% were misclassified, and 6% were classified as indeterminate; sensitivity and specificity for biliary atresia were 97% and 82%, respectively. Radionuclide imaging with the newer technetium-99m-labeled hepatobiliary radiopharmaceuticals appears promising for the non-invasive diagnosis of biliary atresia.

• Research Organization: Univ. of Colorado Health Sciences Center, Denver
• OSTI ID: 6085967
• Journal Information: Radiology; (United States), Vol. 146:2
• Country of Publication: United States
• Language: English

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INFANTS
ISOMERIC NUCLEI
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550601* - Medicine- Unsealed Radionuclides in Diagnostics