Linkage analysis in German breast cancer families with early onset of the disease, using highly polymorphic markers from the chromosome 17q11-q24 region

Journal Article · Thu Apr 01 00:00:00 EST 1993 · American Journal of Human Genetics; (United States)

OSTI ID:6083086

Zimmermann, W; Bender, E; Rohde, K; Reis, A; Krause, H; Prokoph, H; Werner, S; Scherneck, S ^[1]; Wiseman, R; Futreal, A ^[2]

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1. Freie Universitaet, Berlin (Germany)
2. National Inst. of Environmental Health Sciences, Research Triangle Park, NC (United States)

Linkage analysis in German breast cancer families with early onset of the disease by using six markers on chromosome 17q11-q24 has been carried out. In the region between markers D17S250 and GH, three markers showed positive LOD scores at an estimated distance of zero. Evidence for linkage is greatest for D17S250, with a LOD score of 2.42. 14 refs., 1 fig., 1 tab.

• OSTI ID: 6083086
• Journal Information: American Journal of Human Genetics; (United States), Vol. 52:4; ISSN 0002-9297
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HUMAN CHROMOSOME 17
GENETIC MAPPING
MAMMARY GLANDS
NEOPLASMS
DNA HYBRIDIZATION
FEDERAL REPUBLIC OF GERMANY
RFLPS
BODY
CHROMOSOMES
DEVELOPED COUNTRIES
DISEASES
EUROPE
GLANDS
HUMAN CHROMOSOMES
HYBRIDIZATION
MAPPING
ORGANS
WESTERN EUROPE
550400* - Genetics