The order and orientation of a cluster of metalloproteinase genes, stromelysin 2, collagenase, and stromelysin, together with D11S385, on chromosome 11q22-q23
Journal Article
·
· Genomics; (United States)
- Univ. of Birmingham (United Kingdom)
- ICI Pharmaceuticals, Cheshire (United Kingdom)
A cluster of metalloproteinase genes (stromelysin, fibroblast collagenase, and stromelysin 2), together with the anonymous DNA marker D11S385, was mapped using pulsed-field gel electrophoresis to a 135-kb region of chromosome 11q22-q23. The physical proximity of these markers was subsequently confirmed using two YAC clones, and their relative order was established as stromelysin 2-collagenase-stromelysin- D11S385. The pattern of marker representation in a panel of radiation-reduced chromosome 11 hybrids suggests that the metalloproteinase gene/D11S385 cluster is orientated with STMY2 closest to the centromere. 11 refs., 1 fig., 1 tab.
- OSTI ID:
- 6082588
- Journal Information:
- Genomics; (United States), Journal Name: Genomics; (United States) Vol. 16:1; ISSN GNMCEP; ISSN 0888-7543
- Country of Publication:
- United States
- Language:
- English
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