Mechanism of bronchoconstriction

Journal Article · Fri Jan 01 04:00:00 EST 1965 · Arch. Environ. Health; (United States)

DOI:https://doi.org/10.1080/00039896.1965.10663979· OSTI ID:6081860

Nadel, J A; Salem, H; Tamplin, B; Tokiwa, Y

Exposure of humans to 4 to 6 ppM SO/sub 2/ decreased ratio of airway resistance to thoracic gas volume an average of 39% usually within 10 sec to 4 min. Atropine effectively blocked this change but did not decrease irritation or coughing during breathing. SO/sub 2/ delivered via tracheal cannula increased total pulmonary resistance in cats a mean of 246%. SO/sub 2/ delivered to upper airways only increased R/sub L/ a mean of 331%. Atropine or cooling of cervical vagosympathetic nerves negated this response. Rapidity of response and subsequent reversal suggests that changes in smooth muscle tone cause bronchoconstriction. Sensory receptors are in upper and lower airways, as lower airway constriction occurred with upper airway exposure. SO/sub 2/ acts like other stimuli producing bronchoconstriction.

• OSTI ID: 6081860
• Journal Information: Arch. Environ. Health; (United States), Journal Name: Arch. Environ. Health; (United States) Vol. 10; ISSN AEHLA
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AIR POLLUTION
ALKALOIDS
ANIMALS
ATROPINE
AUTONOMIC NERVOUS SYSTEM
BIOLOGICAL EFFECTS
BRONCHI
CATS
CHALCOGENIDES
COENZYMES
CONTRACTION
DRUGS
HAZARDS
HEALTH HAZARDS
MAMMALS
MAN
MUSCLES
NADP
NERVES
NERVOUS SYSTEM
NUCLEOTIDES
ORGANIC COMPOUNDS
OXIDES
OXYGEN COMPOUNDS
PARASYMPATHOLYTICS
POLLUTION
PRIMATES
RESPIRATION
RESPIRATORY SYSTEM
RESPONSE MODIFYING FACTORS
SULFUR COMPOUNDS
SULFUR DIOXIDE
SULFUR OXIDES
VAGUS
VERTEBRATES