Comparison of somatic reversions between the ivory allele and transposon-caused mutant alleles at the white locus of Drosophila melanogaster after larval treatment with X rays and ethyl methanesulfonate

Journal Article · Mon Jul 01 00:00:00 EDT 1985 · Genetics; (United States)

OSTI ID:6081246

Ryo, H; Yoo, M A; Fujikawa, K; Kondo, S

Somatic reversion of strains with the ivory (wi) allele, a mutation associated with a tandem duplication of a DNA sequence at the white locus, increased with the age of larvae at the time of X-irradiation as expected from the increase in the number of target cells. In contrast, two independently isolated strains with unstable w+ loci associated with insertion of transposable elements showed higher reversion frequencies after treatment with X rays or ethyl methanesulfonate (EMS) at early larval stages than at late stages. Nevertheless, both the wi strain and the two unstable w+ strains reverted at nearly equal rates after treatment with X rays or EMS at early larval stages. Possible similarity in hot spot structure for the high reversibility of the two types of mutations is discussed in relation to production of presumed mutator-type cofactors specific to the transposon-caused mutations at early larval stages.

• Research Organization: Osaka Univ., Japan
• OSTI ID: 6081246
• Journal Information: Genetics; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
EMS
GENETIC EFFECTS
LARVAE
GENETIC RADIATION EFFECTS
DROSOPHILA
PHENOTYPE
REVERTANTS
SOMATIC MUTATIONS
X RADIATION
ANIMALS
ARTHROPODS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
DIPTERA
ELECTROMAGNETIC RADIATION
ESTERS
FLIES
FRUIT FLIES
INSECTS
INVERTEBRATES
IONIZING RADIATIONS
MUTAGENS
MUTANTS
MUTATIONS
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
SULFONIC ACID ESTERS
560154* - Radiation Effects on Animals- Basic Studies- (-1987)
560304 - Chemicals Metabolism & Toxicology- Invertebrates- (-1987)