Thallium 201 uptake in kidneys and heart as an indicator of prognosis in septic shock in the rat

Journal Article · Wed Mar 01 04:00:00 EST 1989 · Circ. Shock; (United States)

OSTI ID:6073483

Senda, M; Ahmad, M; Rubin, R; Strauss, H W

The change in distribution of cardiac output in septic shock was examined by radionuclide imaging with thallium 201 thallous chloride (/sup 201/Tl) which allows noninvasive evaluation of relative blood flow to various organs except for the brain. Pseudomonas aeruginosa (1 X 10(9)-2 X 10(10) organisms) were inoculated into the thigh of rats 18-24 hr before the study. The mean arterial pressure was measured with an intracarotid catheter. Fractional blood flow to the heart, kidneys, and liver was evaluated as organ uptake of /sup 201/Tl. Those with zero or less than 5% kidney uptake (n = 8) had a high heart uptake and all died within 3 hr even if their pressure was maintained. In contrast, 20 out of 24 rats with kidney uptake greater than 5% survived for more than 6 hr. Those results suggest that the kidney uptake, representing fractional renal blood flow, is an excellent indicator of short-term prognosis in septic shock.

• Research Organization: Massachusetts General Hospital, Boston (USA)
• OSTI ID: 6073483
• Journal Information: Circ. Shock; (United States), Journal Name: Circ. Shock; (United States) Vol. 27:3; ISSN CRSHA
• Country of Publication: United States
• Language: English

Related Subjects

550601* -- Medicine-- Unsealed Radionuclides in Diagnostics
62 RADIOLOGY AND NUCLEAR MEDICINE
ANIMALS
BACTERIAL DISEASES
BETA DECAY RADIOISOTOPES
BLOOD FLOW
BLOOD PRESSURE
BODY
CARDIOVASCULAR SYSTEM
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSIS
DIGESTIVE SYSTEM
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
GLANDS
HEART
HEAVY NUCLEI
INFECTIOUS DISEASES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KIDNEYS
LIVER
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
RADIOISOTOPE SCANNING
RADIOISOTOPES
RATS
RODENTS
SECONDS LIVING RADIOISOTOPES
THALLIUM 201
THALLIUM ISOTOPES
UPTAKE
VERTEBRATES