Nonuniformity in myocardial accumulation of fluorine-18-fluorodeoxyglucose in normal fasted humans

Journal Article · Thu Nov 01 00:00:00 EST 1990 · Journal of Nuclear Medicine; (USA)

OSTI ID:6070925

Gropler, R J; Siegel, B A; Lee, K J; Moerlein, S M; Perry, D J; Bergmann, S R; Geltman, E M ^[1]

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1. Edward Mallinckrodt Institute of Radiology, St. Louis, MO (USA)

In initial studies using fluorine-18-fluorodeoxyglucose (FDG) in normal fasted subjects, we observed disparities in the regional myocardial accumulation of this tracer. Accordingly, we systematically evaluated regional myocardial FDG accumulation in comparison with regional myocardial perfusion assessed with oxygen-15-water and oxidative metabolism assessed with carbon-11-acetate in nine normal subjects (four studied after a 5-hr fast and five studied both fasted and following glucose loading). Under fasting conditions, myocardial accumulation of FDG in the septum and anterior wall averaged 80% of that in the lateral and posterior walls (p less than 0.03). In contrast, after glucose loading the regional distribution of myocardial FDG accumulation became more homogeneous. Regional myocardial perfusion, oxidative metabolism, and accumulation of carbon-11-acetate were homogeneous under both conditions. Thus, under fasting conditions there are regional variations in myocardial accumulation of FDG, which are visually apparent, are not associated with concomitant changes in oxidative metabolism or perfusion, and cannot be attributed to partial-volume effects. This significant heterogeneity may limit the specificity of PET with FDG for detecting myocardial ischemia in fasting subjects.

• OSTI ID: 6070925
• Journal Information: Journal of Nuclear Medicine; (USA), Vol. 31:11; ISSN 0161-5505
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
ISCHEMIA
DIAGNOSIS
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
ACETATES
BLOOD PRESSURE
CARBON 11
FASTING
FLUORINE 18
GLUCOSE
MAN
MYOCARDIUM
OXYGEN 15
PATIENTS
PERFUSED ORGANS
POSITRON COMPUTED TOMOGRAPHY
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CARBON ISOTOPES
CARBOXYLIC ACID SALTS
CARDIOVASCULAR DISEASES
CARDIOVASCULAR SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
DISTRIBUTION
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
FLUORINE ISOTOPES
HEART
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
MONOSACCHARIDES
MUSCLES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VASCULAR DISEASES
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics