Recurrence of posterior uveal melanoma after /sup 60/Co episcleral plaque therapy

Journal Article · Wed Mar 01 00:00:00 EST 1989 · Ophthalmology (Rochester, Minn.); (United States)

DOI:https://doi.org/10.1016/S0161-6420(89)32882-X· OSTI ID:6070859

Karlsson, U L; Augsburger, J J; Shields, J A; Markoe, A M; Brady, L W; Woodleigh, R

The authors analyzed the clinical and follow-up data on 277 selected patients with primary choroidal or ciliochoroidal melanoma who were treated with /sup 60/Co plaque radiotherapy between 1976 and 1982. Local recurrence of the irradiated melanoma developed in 39 (14%) patients during the follow-up interval. The 5-year tumor recurrence rate (Kaplan-Meier) was estimated to be 12%. Multivariate prognostic factor analysis (Cox proportional hazards modeling) identified the largest linear tumor dimension and proximity of the posterior margin of the tumor to the optic nerve head as predictors of recurrence. The 5-year survival rate of patients whose tumors recurred (58%) was significantly (log-rank test P = 0.0023) worse than that of patients whose tumor remained clinically controlled (82%).

• Research Organization: Hahnemann Univ. School of Medicine, Philadelphia, PA (USA)
• OSTI ID: 6070859
• Journal Information: Ophthalmology (Rochester, Minn.); (United States), Vol. 96:3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
MELANOMAS
RADIOTHERAPY
UVEA
COBALT 60
MULTIVARIATE ANALYSIS
PATIENTS
SURVIVAL CURVES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BODY AREAS
COBALT ISOTOPES
DISEASES
EYES
FACE
HEAD
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MATHEMATICS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
SENSE ORGANS
STATISTICS
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)