Clearance of chlamydial elementary bodies from the conjunctival sac

Journal Article · Wed Jul 01 00:00:00 EDT 1987 · Invest. Ophthalmol. Visual Sci.; (United States)

OSTI ID:6070807

Taylor, H R; Velez, V L

The rate of disappearance of inactivated Chlamydia trachomatis elementary body (EB) preparations from the conjunctival sac was studied in monkeys. Direct fluorescent antibody (DFA) cytology showed that the majority of EB had been cleared from the eye within 24 hr of the inoculation of 1 X 10(6) inactivated EB, although small numbers of EB could be detected for up to 144 hr. The rate of clearance in normal and ocular immune animals did not differ, and formalin-killed and UV-inactivated EBs disappeared at a comparable rate. These studies suggest that chlamydial EB are cleared relatively quickly from the eye and support the notion that EBs detected by DFA cytology indicate the presence of current infection.

• Research Organization: Johns Hopkins Univ., Baltimore, MD
• OSTI ID: 6070807
• Journal Information: Invest. Ophthalmol. Visual Sci.; (United States), Vol. 28:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BACTERIA
BIOLOGICAL RADIATION EFFECTS
ELEMENTARY PARTICLES
CLEARANCE
CONJUNCTIVA
FLUORESCENCE
MONKEYS
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
LUMINESCENCE
MAMMALS
MEMBRANES
MICROORGANISMS
MUCOUS MEMBRANES
ORGANS
PRIMATES
RADIATION EFFECTS
RADIATIONS
SENSE ORGANS
VERTEBRATES
560130* - Radiation Effects on Microorganisms