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Radioprotective effects of dimethyl sulfoxide in golden hamster embryo cells exposed to gamma rays at 77 K. II. Protection from lethal, chromosomal, and DNA damage

Journal Article · · Radiation Research; (USA)
DOI:https://doi.org/10.2307/3577697· OSTI ID:6068209
; ; ; ;  [1]
  1. Yokohama City Univ. (Japan)
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Golden hamster embryo cells were exposed to 137Cs gamma rays in the presence or absence of dimethyl sulfoxide at both 310 and 77 K. Dimethyl sulfoxide gave significant protection against cell killing at both 310 and 77 K. The extent of radioprotection with 1.28 M dimethyl sulfoxide at 77 K was 85-89% of the lethal effects observed in the absence of dimethyl sulfoxide at 310 K; the dose-modifying factor was 5.7. Dimethyl sulfoxide also exerted protected against gamma-ray-induced DNA single-strand breaks and chromosomal aberrations with a maximum protection of 80-100% at a dimethyl sulfoxide concentration of 1.28 M at 77 K. At 77 K, H atoms, ion holes, and electrons can migrate through frozen cells but OH radicals cannot diffuse. Thus the protective effects of dimethyl sulfoxide against cell killing, chromosomal aberrations, and DNA single-strand breaks at 77 K may be due to the scavenging of H atoms or other ions, rather than OH radicals.

OSTI ID:
6068209
Journal Information:
Radiation Research; (USA), Journal Name: Radiation Research; (USA) Vol. 124:1; ISSN RAREA; ISSN 0033-7587
Country of Publication:
United States
Language:
English

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Related Subjects

560120* -- Radiation Effects on Biochemicals
Cells
& Tissue Culture
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALKALI METAL ISOTOPES
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CESIUM 137
CESIUM ISOTOPES
CHROMOSOMAL ABERRATIONS
DMSO
ELECTROMAGNETIC RADIATION
ELECTRON SPIN RESONANCE
EMBRYONIC CELLS
GAMMA RADIATION
GENETIC EFFECTS
GENETIC RADIATION EFFECTS
HAMSTERS
IONIZING RADIATIONS
ISOTOPES
MAGNETIC RESONANCE
MAMMALS
MUTATIONS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOINDUCTION
RADIOISOTOPES
RADIOSENSITIVITY EFFECTS
RESONANCE
RODENTS
STRAND BREAKS
SULFOXIDES
VERTEBRATES
YEARS LIVING RADIOISOTOPES