Effect of medroxyprogesterone acetate (Provera) on ovarian radiosensitivity
Medroxyprogesterone acetate (Provera) is a drug that is commonly given to young women with cancer during chemotherapy and radiation to control heavy bleeding associated with anovulation. Because hypothalamic-pituitary-ovarian suppression has been associated with ovarian protection from the effects of chemotherapy and medroxyprogesterone acetate has been identified as a radiosensitizing agent, we explored the effects of medroxyprogesterone acetate on a rat model with known radiation injury characteristics. Sprague-Dawley rats were treated with medroxyprogesterone acetate or vehicle from day 22 to day 37 of life and were either irradiated or sham-irradiated on day 30 of life and then killed on day 44. Radiation with medroxyprogesterone acetate administration produced a greater loss in preantral and healthy control follicles than in control follicles. No suppression of luteinizing hormone or follicle-stimulating hormone had occurred by day 30 but ovarian glutathione content was reduced. These findings indicate that the administration of medroxyprogesterone acetate with radiotherapy may enhance ovarian injury.
- Research Organization:
- Univ. of Calgary/Foothills Hospital, Alberta (Canada)
- OSTI ID:
- 6067666
- Journal Information:
- Am. J. Obstet. Gynecol.; (United States), Vol. 160:4
- Country of Publication:
- United States
- Language:
- English
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OVARIES
RADIOSENSITIVITY
RADIOSENSITIZERS
EVALUATION
BIOLOGICAL MODELS
GLUTATHIONE
GONADOTROPINS
RADIATION INJURIES
RADIOSENSITIVITY EFFECTS
RATS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
DRUGS
FEMALE GENITALS
GONADS
HORMONES
INJURIES
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PEPTIDES
PITUITARY HORMONES
POLYPEPTIDES
PROTEINS
RADIATION EFFECTS
RADIOPROTECTIVE SUBSTANCES
RODENTS
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560152* - Radiation Effects on Animals- Animals