LHRH and LH in peripubertal female rats following prenatal and/or postnatal ethanol exposure
The effects of pre- and postnatal exposure to ethanol (ETHO) on LHRH and LH were investigated. Pregnant and/or lactating dams were fed ETHOD during: (1) gestation, (2) lactation, or (3) gestation-lactation. Female offspring were decapitated at 30 or 40 days-of-age; trunk blood was collected for plasma LH RIA; and hypothalamic tissues were collected for LHRH RIA. Hypothalamic LHRH content of all ETOH-exposed groups was less than that of non-ETOH-fed controls at 30 and 40 days-of-age. Plasma LH concentrations of all ETOH-exposed groups were less than those of non-ETOD-fed controls at 30 and 40 days-of-age. Also, at 30 and 40 days-of-age, the plasma LH concentrations of the animals exposed to ETOH during lactation and gestation-lactation were less than those of the animals exposed to ETOH during gestation. These data suggest that ETOH exposure during gestation and/or lactation negatively affects hypothalamic LHRH content of femal rat offspring. Decreased hypothalamic LHRH content with corresponding lowered plasma LH concentration suggests that ETOH influences development or maturation of hypothalamic LHRH neurons by possibly decreasing their number or synthesizing capability.
- Research Organization:
- Texas A and M Univ., College Station (USA)
- OSTI ID:
- 6066061
- Journal Information:
- Life Sci.; (United States), Vol. 44:17
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
ETHANOL
BIOLOGICAL EFFECTS
LH
BIOSYNTHESIS
LH-RH
HYPOTHALAMUS
LACTATION
NERVE CELLS
PREGNANCY
PROGENY
RADIOIMMUNOASSAY
RATS
ALCOHOLS
ANIMAL CELLS
ANIMALS
BODY
BRAIN
CENTRAL NERVOUS SYSTEM
GONADOTROPINS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
LIBERINS
MAMMALS
NERVOUS SYSTEM
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
PITUITARY HORMONES
RADIOASSAY
RADIOIMMUNOLOGY
RODENTS
SOMATIC CELLS
SYNTHESIS
TRACER TECHNIQUES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology
550201 - Biochemistry- Tracer Techniques