Enhanced arrhythmogenicity of Freon 113 by hypoxia in the perfused rat heart

Journal Article · Tue May 01 00:00:00 EDT 1990 · Toxicology and Industrial Health; (USA)

DOI:https://doi.org/10.1177/074823379000600310· OSTI ID:6065848

Kawakami, T; Takano, T; Araki, R ^[1]

---

1. Tokyo Medical and Dental Univ. Faculty of Medicine (Japan)

The interaction of Freon 113 (1,1,2-trichloro-1,2,2-trifluoroethane) and hypoxia on the heart conduction system was studied using electrocardiogram monitoring of isolated perfused rat hearts. Freon 113 (0.2 mM) alone elicited significant atrioventricular conduction delay (p less than 0.05) and heart rate decrease (p less than 0.01), which were significantly enhanced by hypoxia (75% oxygen decrease), for instance, resulting in 2:1 AV block. The data suggest that arrhythmogenicity of Freon 113 on the heart conduction system may be enhanced synergistically by hypoxia.

• OSTI ID: 6065848
• Journal Information: Toxicology and Industrial Health; (USA), Journal Name: Toxicology and Industrial Health; (USA) Vol. 6:3-4; ISSN TIHEE; ISSN 0748-2337
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
ANOXIA
BIOLOGICAL EFFECTS
BODY
CARDIOVASCULAR SYSTEM
DIAGRAMS
ELECTROCARDIOGRAMS
FREONS
HALOGENATED ALIPHATIC HYDROCARBONS
HEART
MAMMALS
METABOLISM
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PERFUSED ORGANS
RATS
RODENTS
SENSITIVITY
SYNERGISM
VERTEBRATES