Evaluation of mouse lip mucosa reactions after combinations of cis-diammine-1,1-cyclobutanedicarboxylate platinum (II) (CBDCA) and irradiation: single and fractionated treatments
Journal Article
·
· Int. J. Radiat. Oncol., Biol. Phys.; (United States)
The influence of CBDCA (JM8) on the radiation-induced mouse lip mucosal reactions has been tested. Both single and fractionated drug doses were used intraperitoneally at 60 mg/kg and 5 X 25 mg/kg respectively. A single injection of CBDCA did not alter the response to a single radiation dose, whether the drug was given at different time intervals from 24 hr prior, to 96 hr after irradiation. A concomitant treatment of daily CBDCA injections and irradiations for 5 consecutive days demonstrated no change of the capacity to repair sublethal radiation damage. When two equal sized radiation doses were separated by 10 days and CBDCA was administered daily from day 3 to 7, the ability to repopulate the lip mucosa epithelium during the radiation-free period was not influenced.
- Research Organization:
- University Hospital St. Rafal (K.U. Leuven), Belgium
- OSTI ID:
- 6063827
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Journal Name: Int. J. Radiat. Oncol., Biol. Phys.; (United States) Vol. 13:9; ISSN IOBPD
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
560152* -- Radiation Effects on Animals-- Animals
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DIGESTIVE SYSTEM
DOSES
EPITHELIUM
FRACTIONATED IRRADIATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IRRADIATION
MAMMALS
MEMBRANES
MICE
MUCOUS MEMBRANES
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
TISSUES
VERTEBRATES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACUTE EXPOSURE
ACUTE IRRADIATION
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
DIGESTIVE SYSTEM
DOSES
EPITHELIUM
FRACTIONATED IRRADIATION
INJECTION
INTAKE
INTRAPERITONEAL INJECTION
IRRADIATION
MAMMALS
MEMBRANES
MICE
MUCOUS MEMBRANES
ORAL CAVITY
ORGANIC COMPOUNDS
ORGANOMETALLIC COMPOUNDS
RADIATION DOSES
RADIATION EFFECTS
RADIOSENSITIVITY EFFECTS
RECOVERY
REPAIR
RODENTS
TISSUES
VERTEBRATES