Evaluation of mouse lip mucosa reactions after combinations of cis-diammine-1,1-cyclobutanedicarboxylate platinum (II) (CBDCA) and irradiation: single and fractionated treatments
The influence of CBDCA (JM8) on the radiation-induced mouse lip mucosal reactions has been tested. Both single and fractionated drug doses were used intraperitoneally at 60 mg/kg and 5 X 25 mg/kg respectively. A single injection of CBDCA did not alter the response to a single radiation dose, whether the drug was given at different time intervals from 24 hr prior, to 96 hr after irradiation. A concomitant treatment of daily CBDCA injections and irradiations for 5 consecutive days demonstrated no change of the capacity to repair sublethal radiation damage. When two equal sized radiation doses were separated by 10 days and CBDCA was administered daily from day 3 to 7, the ability to repopulate the lip mucosa epithelium during the radiation-free period was not influenced.
- Research Organization:
- University Hospital St. Rafal (K.U. Leuven), Belgium
- OSTI ID:
- 6063827
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 13:9
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
EPITHELIUM
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL REPAIR
ORGANOMETALLIC COMPOUNDS
RADIOSENSITIVITY EFFECTS
ACUTE IRRADIATION
FRACTIONATED IRRADIATION
INTRAPERITONEAL INJECTION
MICE
MUCOUS MEMBRANES
ORAL CAVITY
RADIATION DOSES
ACUTE EXPOSURE
ANIMAL TISSUES
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BODY
DIGESTIVE SYSTEM
DOSES
INJECTION
INTAKE
IRRADIATION
MAMMALS
MEMBRANES
ORGANIC COMPOUNDS
RADIATION EFFECTS
RECOVERY
REPAIR
RODENTS
TISSUES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals