Synthesis and 1H-NMR studies of alpha-deuterated analogues of des-Trp1, Nle12-human minigastrin
- Univ. of Padua (Italy)
Three analogues of the tridecapeptide amide H-Leu-(Glu)5-Ala-Tyr-Gly-Nle-Asp-Phe-NH2 were synthetized with alpha-deuterated glutamate residues in specific positions in order to assign unambiguously the 1H NMR spectrum of the parent peptide in water and in water-trifluoroethanol mixtures. The synthetic route is described and the assignment illustrated. A previous, tentative assignment based solely on indirect evidence was partially modified.
- OSTI ID:
- 6062621
- Journal Information:
- Biopolymers; (USA), Vol. 30:7-8; ISSN 0006-3525
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
GASTRIN
MOLECULAR STRUCTURE
AMINO ACID SEQUENCE
CHEMICAL PREPARATION
DEUTERIUM
GLUTAMIC ACID
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
PEPTIDES
PROTONS
TRACER TECHNIQUES
AMINO ACIDS
BARYONS
CARBOXYLIC ACIDS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HORMONES
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
POLYPEPTIDES
PROTEINS
RESONANCE
SPECTRA
STABLE ISOTOPES
SYNTHESIS
550201* - Biochemistry- Tracer Techniques
GASTRIN
MOLECULAR STRUCTURE
AMINO ACID SEQUENCE
CHEMICAL PREPARATION
DEUTERIUM
GLUTAMIC ACID
NMR SPECTRA
NUCLEAR MAGNETIC RESONANCE
PEPTIDES
PROTONS
TRACER TECHNIQUES
AMINO ACIDS
BARYONS
CARBOXYLIC ACIDS
ELEMENTARY PARTICLES
FERMIONS
HADRONS
HORMONES
HYDROGEN ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LIGHT NUCLEI
MAGNETIC RESONANCE
NUCLEI
NUCLEONS
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
PEPTIDE HORMONES
POLYPEPTIDES
PROTEINS
RESONANCE
SPECTRA
STABLE ISOTOPES
SYNTHESIS
550201* - Biochemistry- Tracer Techniques