Cholesterol kinetic effects of dietary fat in CBA/J and C57BR/cdJ mice

Conference · Mon Feb 26 00:00:00 EST 1990 · FASEB Journal (Federation of American Societies for Experimental Biology); (United States)

OSTI ID:6062237

Stewart, J; Kuan, Soniu; Seagrave, R; Patterson, L; Koschorreck, R; Dupont, J ^[1]

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1. Iowa State Univ., Ames (United States)

Small differences in dietary fats cause marked differences in cholesterol metabolism in different strains of mice. CBA/J mice adjust HMGCOA reductase activity and C57BR/cdJ mice change fecal excretion of cholesterol. Phenomenological compartmental modeling of movement of 4{sup 14}C-cholesterol in the two strains of mice fed 40 en % fat, P/S = 0.24 (SFA) or 30 en % fat, P/S = 1 (PUFA) was used to analyze rates of movement between serum, liver, heart, and carcass. The C57 mice had slower movement between all compartments than CBA. Residence times in tissues were longer in mice fed SFA than those fed PUFA diet. The kinetic results are in agreement with the organ concentrations and enzyme activities measured.

• OSTI ID: 6062237
• Report Number(s): CONF-9104107-; CODEN: FAJOE
• Journal Information: FASEB Journal (Federation of American Societies for Experimental Biology); (United States), Vol. 4:3; Conference: 75. annual meeting of the Federation of American Societies for Experimental Biology (FASEB), Atlanta, GA (United States), 21-25 Apr 1991; ISSN 0892-6638
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
CHOLESTEROL
METABOLISM
BIOCHEMICAL REACTION KINETICS
BLOOD SERUM
BODY
CARBON 14 COMPOUNDS
ENZYME ACTIVITY
EXCRETION
HEART
LIVER
MICE
OXIDOREDUCTASES
SATURATION
TRACER TECHNIQUES
ANIMALS
CARBON COMPOUNDS
CARDIOVASCULAR SYSTEM
CLEARANCE
DIGESTIVE SYSTEM
ENZYMES
GLANDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
RODENTS
STEROIDS
STEROLS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques