Intestinal absorption, liver uptake, and excretion of /sup 3/H-folic acid in folic acid-deficient, alcohol-consuming nonhuman primates
Nonhuman primates fed folic acid-deficient diets +/- 30% kcal ethanol were used to determine alcohol effects on megaloblastic anemia development and folate bioavailability. Lower hemoglobin (Hb) and red blood cell (RBC) counts and higher mean corpuscular volume (MCV) occurred after 13 wk in alcohol-fed monkeys, later in controls. Plasma, RBC, and liver folate declined and urinary formiminoglutamic acid (FIGLU) was elevated in both groups with FIGLU increasing more among alcohol-fed monkeys at 38 wk. After 40 wk, the bioavailability of oral /sup 3/H-folic acid was investigated and showed increased fecal and reduced urinary tritium excretion in alcohol-fed monkeys compared with controls while plasma uptake and liver and whole body tritium retention were similar in both groups. These observations demonstrate that chronic alcohol consumption impairs folate coenzymes, accelerates appearance of hematologic indices of megaloblastic anemia, and causes possible malabsorption of enterohepatically circulated folates in folate deficiency even when other essential nutrients are provided.
- Research Organization:
- Harvard Univ. School of Public Health, Cambridge, MA
- OSTI ID:
- 6062121
- Journal Information:
- Am. J. Clin. Nutr.; (United States), Vol. 46:3
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
ETHANOL
TOXICITY
FOLIC ACID
INTESTINAL ABSORPTION
METABOLISM
ANEMIAS
BIOLOGICAL AVAILABILITY
BLOOD COUNT
DIET
EXCRETION
FECES
HEMOGLOBIN
LIVER
MONKEYS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
ABSORPTION
ALCOHOLS
AMINO ACIDS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BODY
CARBOXYLIC ACIDS
CLEARANCE
DIGESTIVE SYSTEM
DISEASES
DRUGS
GLANDS
GLOBIN
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
MAMMALS
MATERIALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
PTERIDINES
SYMPTOMS
VERTEBRATES
VITAMIN B GROUP
VITAMINS
WASTES
560300* - Chemicals Metabolism & Toxicology
550501 - Metabolism- Tracer Techniques