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Intestinal absorption, liver uptake, and excretion of /sup 3/H-folic acid in folic acid-deficient, alcohol-consuming nonhuman primates

Journal Article · · Am. J. Clin. Nutr.; (United States)
OSTI ID:6062121
;
Nonhuman primates fed folic acid-deficient diets +/- 30% kcal ethanol were used to determine alcohol effects on megaloblastic anemia development and folate bioavailability. Lower hemoglobin (Hb) and red blood cell (RBC) counts and higher mean corpuscular volume (MCV) occurred after 13 wk in alcohol-fed monkeys, later in controls. Plasma, RBC, and liver folate declined and urinary formiminoglutamic acid (FIGLU) was elevated in both groups with FIGLU increasing more among alcohol-fed monkeys at 38 wk. After 40 wk, the bioavailability of oral /sup 3/H-folic acid was investigated and showed increased fecal and reduced urinary tritium excretion in alcohol-fed monkeys compared with controls while plasma uptake and liver and whole body tritium retention were similar in both groups. These observations demonstrate that chronic alcohol consumption impairs folate coenzymes, accelerates appearance of hematologic indices of megaloblastic anemia, and causes possible malabsorption of enterohepatically circulated folates in folate deficiency even when other essential nutrients are provided.
Research Organization:
Harvard Univ. School of Public Health, Cambridge, MA
OSTI ID:
6062121
Journal Information:
Am. J. Clin. Nutr.; (United States), Journal Name: Am. J. Clin. Nutr.; (United States) Vol. 46:3; ISSN AJCNA
Country of Publication:
United States
Language:
English

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Related Subjects

550501 -- Metabolism-- Tracer Techniques
560300* -- Chemicals Metabolism & Toxicology
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ABSORPTION
ALCOHOLS
AMINO ACIDS
ANEMIAS
ANIMALS
AROMATICS
AZAARENES
BIOLOGICAL AVAILABILITY
BIOLOGICAL MATERIALS
BIOLOGICAL WASTES
BLOOD COUNT
BODY
CARBOXYLIC ACIDS
CLEARANCE
DIET
DIGESTIVE SYSTEM
DISEASES
DRUGS
ETHANOL
EXCRETION
FECES
FOLIC ACID
GLANDS
GLOBIN
HEMATINICS
HEMATOLOGIC AGENTS
HEMIC DISEASES
HEMOGLOBIN
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
INTESTINAL ABSORPTION
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LIVER
MAMMALS
MATERIALS
METABOLISM
MONKEYS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
PORPHYRINS
PRIMATES
PROTEINS
PTERIDINES
SYMPTOMS
TOXICITY
TRACER TECHNIQUES
TRITIUM COMPOUNDS
UPTAKE
VERTEBRATES
VITAMIN B GROUP
VITAMINS
WASTES