A fibronectin receptor on Candida albicans mediates adherence of the fungus to extracellular matrix

Journal Article · Fri Mar 01 04:00:00 EST 1991 · Journal of Infectious Diseases; (USA)

DOI:https://doi.org/10.1093/infdis/163.3.604· OSTI ID:6061466

Klotz, S A; Smith, R L ^[1]

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1. Overton Brooks VA Medical Center, Shreveport, LA (USA)

Binding of fibronectin, an extracellular matrix (ECM) protein, to Candida albicans was measured, and adherence of the fungus to immobilized ECM proteins, fibronectin, laminin, types I and IV collagen, and subendothelial ECM was studied. 125I-labeled fibronectin was inhibited from binding to the fungus by unlabeled human plasma fibronectin and by Arg-Gly-Asp (RGD), Gly-Arg-Gly-Glu-Ser-Pro (GRGESP), and Gly-Arg-Gly-Asp-Thr-Pro (GRGDTP), but binding was not inhibited by Gly-Arg-Gly-Asp-Ser-Pro. Soluble fibronectin, RGD, GRGESP, and GRGDTP also inhibited fungal adherence to the individual immobilized ECM proteins in a complex pattern, but only soluble fibronectin (10(-7) M) inhibited fungal adherence to subendothelial ECM. Thus, C. albicans possesses at least one type of cell surface receptor for binding soluble fibronectin that can be inhibited with peptides. This receptor apparently is used to bind the fungus to immobilized ECM proteins and to subendothelial ECM and may play a role in the initiation of disseminated disease by bloodborne fungi by providing for adherence of the microorganisms to ECM proteins.

• OSTI ID: 6061466
• Journal Information: Journal of Infectious Diseases; (USA), Journal Name: Journal of Infectious Diseases; (USA) Vol. 163:3; ISSN JIDIA; ISSN 0022-1899
• Country of Publication: United States
• Language: English

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59 BASIC BIOLOGICAL SCIENCES
ADHESION
BETA DECAY RADIOISOTOPES
BIOCHEMICAL REACTION KINETICS
CANDIDA
DAYS LIVING RADIOISOTOPES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EUMYCOTA
FUNGAL DISEASES
FUNGI
INFECTIOUS DISEASES
INTERMEDIATE MASS NUCLEI
IODINE 125
IODINE ISOTOPES
ISOTOPES
KINETICS
MEMBRANE PROTEINS
MICROORGANISMS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
PATHOGENESIS
PLANTS
PROTEINS
RADIOISOTOPES
REACTION KINETICS
RECEPTORS
YEASTS