Effect of TCDD on ACARAT activity and vitamin A accumulation in the kidney of male Sprague-Dawley rats
Previous studies have shown that rats treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) exhibit symptoms of vitamin A deficiency, including hypophagia, failure of normal growth, loss of hepatic vitamin A and accumulation of vitamin A in the kidney. They observed that male Sprague-Dawley rats treated with a single dose of TCDD gained less weight than control rats over a 12 day period. Treated rats showed a progressive loss of hepatic retinyl esters to levels 55% that of control rats. Treated rats accumulated renal vitamin A, with retinyl palmitate levels reaching 5.2x that of control animals, while retinol levels were elevated to 1.5x that of control rats. The ratio of retinyl palmitate to retinol was significantly greater in treated rats than in the control rats. Acyl CoA:Retinol Acyl Transferase (ACARART) activity was 2x greater in kidneys from treated rats, and positively correlated with retinyl palmitate concentrations. They suggest that accumulation of retinyl esters in the kidney occurs as a result of retinol esterification, in response to the TCDD-induced vitamin A deficiency.
- Research Organization:
- Michigan State Univ., East Lansing
- OSTI ID:
- 6060563
- Report Number(s):
- CONF-870644-
- Journal Information:
- Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States), Journal Name: Fed. Proc., Fed. Am. Soc. Exp. Biol.; (United States) Vol. 46:6; ISSN FEPRA
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMALS
BIOSYNTHESIS
BODY
CARBOXYLIC ACID ESTERS
CHEMICAL REACTIONS
DIGESTIVE SYSTEM
DIOXIN
ENZYME ACTIVITY
ENZYMES
ESTERIFICATION
ESTERS
GLANDS
HETEROCYCLIC COMPOUNDS
KIDNEYS
LIVER
MAMMALS
NUTRITIONAL DEFICIENCY
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
RATS
RETINOIC ACID
RODENTS
SYNTHESIS
TOXICITY
TRANSFERASES
VERTEBRATES
VITAMIN A
VITAMINS