Cambridge glioma trial of misonidazole and radiation therapy with associated pharmacokinetic studies
Journal Article
·
· Cancer Clin. Trials; (United States)
OSTI ID:6059688
Fifty-five patients with grade 3 and 4 supratentorial astrocytomas, were randomized into a three-limb study. At 9 months after the last treatment there were no differences in survival between the treatment groups. No cases of peripheral neuropathy were seen. Investigations into the possible cause of this are presented. It is thought that microsomal enzyme induction by the anticonvulsants phenobarbitone and phenytoin resulted in increased 0-demethylation of the misonidazole. Clinical data to confirm this view are presented. Current MRC protocols of misonidazole studies on gliomas and carcinomas of the cervix and head and neck are summarized.
- OSTI ID:
- 6059688
- Journal Information:
- Cancer Clin. Trials; (United States), Journal Name: Cancer Clin. Trials; (United States) Vol. 3:3; ISSN CCTRD
- Country of Publication:
- United States
- Language:
- English
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560151* -- Radiation Effects on Animals-- Man
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTICONVULSANTS
ANTINEOPLASTIC DRUGS
ASTROCYTOMAS
AZOLES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
FRACTIONATED IRRADIATION
GLIOMAS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MEDICINE
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PHARMACOLOGY
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
SURVIVAL TIME
THERAPY
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANTICONVULSANTS
ANTINEOPLASTIC DRUGS
ASTROCYTOMAS
AZOLES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
DISEASES
DRUGS
FRACTIONATED IRRADIATION
GLIOMAS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
IRRADIATION
MEDICINE
MISONIDAZOLE
NEOPLASMS
NERVOUS SYSTEM DISEASES
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATIENTS
PHARMACOLOGY
RADIOLOGY
RADIOSENSITIVITY EFFECTS
RADIOSENSITIZERS
RADIOTHERAPY
SURVIVAL TIME
THERAPY