Arsenic exposure, smoking, and lung cancer in smelter workers--a case-control study

Journal Article · Sun Sep 15 04:00:00 EDT 1991 · American Journal of Epidemiology; (United States)

OSTI ID:6058313

Jaerup, L P; Pershagen, G ^[1]

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1. Department of Environmental Hygiene, Karolinska Institutet, Stockholm (Sweden)

A cohort of 3,916 Swedish copper smelter workers employed for at least 3 months between 1928 and 1967 was followed up through 1981. Arsenic exposure was estimated for different time periods at each workplace within the smelter. Detailed job records were linked to the exposure matrix, thus forming individual cumulative arsenic exposure measures for each smelter worker. Smoking history was collected for 107 lung cancer cases and 214 controls from the cohort. Lung cancer risks were positively related to cumulative arsenic exposure with smoking standardized relative risks ranging from 0.7 to 8.7 in different exposure groups. A negative confounding by smoking was suggested in the higher exposure categories. The interaction between arsenic and smoking for the risk of developing lung cancer was intermediate between additive and multiplicative and appeared less pronounced among heavy smokers.

• OSTI ID: 6058313
• Journal Information: American Journal of Epidemiology; (United States), Journal Name: American Journal of Epidemiology; (United States) Vol. 134:6; ISSN 0002-9262; ISSN AJEPA
• Country of Publication: United States
• Language: English

Related Subjects

560300* -- Chemicals Metabolism & Toxicology
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AEROSOLS
ARSENIC
BODY
CARCINOGENESIS
COLLOIDS
DEVELOPED COUNTRIES
DISEASES
DISPERSIONS
DOSE-RESPONSE RELATIONSHIPS
ELEMENTS
EUROPE
LUNGS
METABOLISM
METALLURGY
NEOPLASMS
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
ORGANS
PATHOGENESIS
PERSONNEL
RESIDUES
RESPIRATORY SYSTEM
RISK ASSESSMENT
SCANDINAVIA
SEMIMETALS
SMELTERS
SMOKES
SOLS
SWEDEN
TOBACCO SMOKES